PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Wendland, M.* ; Willenzon, S.* ; Kocks, J.* ; Davalos-Misslitz, A.C.* ; Hammerschmidt, S.I.* ; Schumann, K.* ; Kremmer, E. ; Sixt, M.* ; Hoffmeyer, A.* ; Pabst, O.* ; Forster, R.*

Lymph node T cell homeostasis relies on steady state homing of dendritic cells.

Immunity 35, 945-957 (2012)
Publ. Version/Full Text Volltext DOI PMC
Closed
Open Access Green as soon as Postprint is submitted to ZB.
Little is known about mechanisms determining the homeostasis of lymphocytes within lymphoid organs. Applying different mouse models, including conditionally proficient Ccr7 gene-targeted mice, we now show that semimature steady state dendritic cells (sDCs) constitutively trafficking into lymph nodes (LNs) were essential contributors to T cell homeostasis in these organs. sDCs provided vascular endothelial growth factor known to support high endothelial venule formation, thus facilitating enhanced homing of T cells to LNs. The presence of sDCs led to increased CCL21 production in T-zone fibroblastic reticular cells. CCL21 is a ligand for CCR7 known to regulate homing as well as retention of T cells in LNs. In addition, we provide evidence that CCL21 binds to the surface of DCs via its heparin-binding domain, further explaining why T cells leave LNs more rapidly in the absence of sDCs. Together, these data reveal multiple roles for sDCs in regulating T cell homeostasis in LNs.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
21.637
4.009
81
82
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Migration; Ccr7; Organs; Sphingosine-1-Phosphate; Chemokines; Receptors; Tolerance; Motility; Egress; Entry
Language english
Publication Year 2012
HGF-reported in Year 2012
ISSN (print) / ISBN 1074-7613
e-ISSN 1097-4180
Journal Immunity
Quellenangaben Volume: 35, Issue: 6, Pages: 945-957 Article Number: , Supplement: ,
Publisher Cell Press
Publishing Place Cambridge, Mass.
Reviewing status Peer reviewed
Institute(s) Institute of Molecular Immunology (IMI)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Immune Response and Infection
PSP Element(s) G-501793-001
PubMed ID 22195748
DOI 10.1016/j.immuni.2011.10.017
WOS ID WOS:000298777300013
Scopus ID 84255177550
Erfassungsdatum 2012-09-25
[➜Report correction]