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Cappello, S. ; Attardo, A.* ; Wu, X.* ; Iwasato, T.* ; Itohara, S.* ; Wilsch-Bräuninger, M.* ; Eilken, H.M. ; Rieger, M. ; Schroeder, T. ; Huttner, W.B.* ; Brakebusch, C.* ; Götz, M.

The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface.

Nat. Neurosci. 9, 1099-1107 (2006)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Stem cell persistence into adulthood requires self-renewal from early developmental stages. In the developing mouse brain, only apical progenitors located at the ventricle are self-renewing, whereas basal progenitors gradually deplete. However, nothing is known about the mechanisms regulating the fundamental difference between these progenitors. Here we show that the conditional deletion of the small Rho-GTPase cdc42 at different stages of neurogenesis in mouse telencephalon results in an immediate increase in basal mitoses. Whereas cdc42-deficient progenitors have normal cell cycle length, orientation of cell division and basement membrane contact, the apical location of the Par complex and adherens junctions are gradually lost, leading to an increasing failure of apically directed interkinetic nuclear migration. These cells then undergo mitoses at basal positions and acquire the fate of basal progenitors. Thus, cdc42 has a crucial role at the apical pole of progenitors, thereby regulating the position of mitoses and cell fate.
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Publication type Article: Journal article
Document type Scientific Article
Keywords CELL-CYCLE; NEUROEPITHELIAL CELLS; SUBVENTRICULAR ZONE; RADIAL GLIA; ASYMMETRIC DISTRIBUTION; ADHERENS JUNCTIONS; BRAIN-DEVELOPMENT; LAYER NEURONS; BETA-CATENIN; MOUSE-BRAIN
Language english
Publication Year 2006
HGF-reported in Year 0
ISSN (print) / ISBN 1097-6256
e-ISSN 1546-1726
Journal Nature Neuroscience
Quellenangaben Volume: 9, Issue: 9, Pages: 1099-1107 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Reviewing status Peer reviewed
Institute(s) Institute of Stem Cell Research (ISF)
POF-Topic(s) 30204 - Cell Programming and Repair
Research field(s) Stem Cell and Neuroscience
PSP Element(s) G-500800-001
PubMed ID 16892058
DOI 10.1038/nn1744
WOS ID 000240080800010
Scopus ID 33748099126
Erfassungsdatum 2006-12-31
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