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Expression profiles of endogenous retroviruses in Old World monkeys.
J. Virol. 80, 4415-4421 (2006)
Publ. Version/Full Text Volltext
DOI
PMC
Human endogenous retroviruses (HERVs) are a major component of the human genome and an active part of the transcriptome. Some HERVs play vital biological roles, while others potentially contribute to diseases. Many HERVs are relatively new in the primate genome, having entered or expanded after the lineages leading to the platyrrhines (New World monkeys) and catarrhines (Old World monkeys and apes) separated. Most HERVs are active in at least some tissues, though tissue specificity is common for most elements. We analyzed multiple tissues from several Old World monkeys using retroviral pol-based DNA microarrays and quantitative PCR methods to determine their ERV expression profiles. The results demonstrate that while many ERVs are active in nonhuman primates, overall the tissue expression specificity is unique to each species. Most striking is that while the majority of HERVs analyzed in this study are expressed in human brain, almost none are expressed in Old World monkey brains or are only weakly expressed.Α
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
LEUKEMIA-VIRUS; RNA EXPRESSION; HUMAN TISSUES; GENE; HUMANS; EVOLUTION; BRAINS; SCHIZOPHRENIA; REINFECTION; CHIMPANZEES
ISSN (print) / ISBN
0022-538X
e-ISSN
1098-5514
Journal
Journal of Virology
Quellenangaben
Volume: 80,
Issue: 9,
Pages: 4415-4421
Publisher
American Society for Microbiology (ASM)
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Virology (VIRO)