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Stengel, A. ; Roos, C.* ; Hunsmann, G.* ; Seifarth, W.* ; Leib-Mösch, C. ; Greenwood, A.D.

Expression profiles of endogenous retroviruses in Old World monkeys.

J. Virol. 80, 4415-4421 (2006)
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Human endogenous retroviruses (HERVs) are a major component of the human genome and an active part of the transcriptome. Some HERVs play vital biological roles, while others potentially contribute to diseases. Many HERVs are relatively new in the primate genome, having entered or expanded after the lineages leading to the platyrrhines (New World monkeys) and catarrhines (Old World monkeys and apes) separated. Most HERVs are active in at least some tissues, though tissue specificity is common for most elements. We analyzed multiple tissues from several Old World monkeys using retroviral pol-based DNA microarrays and quantitative PCR methods to determine their ERV expression profiles. The results demonstrate that while many ERVs are active in nonhuman primates, overall the tissue expression specificity is unique to each species. Most striking is that while the majority of HERVs analyzed in this study are expressed in human brain, almost none are expressed in Old World monkey brains or are only weakly expressed.Α
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Publication type Article: Journal article
Document type Scientific Article
Keywords LEUKEMIA-VIRUS; RNA EXPRESSION; HUMAN TISSUES; GENE; HUMANS; EVOLUTION; BRAINS; SCHIZOPHRENIA; REINFECTION; CHIMPANZEES
Language english
Publication Year 2006
HGF-reported in Year 0
ISSN (print) / ISBN 0022-538X
e-ISSN 1098-5514
Journal Journal of Virology
Quellenangaben Volume: 80, Issue: 9, Pages: 4415-4421 Article Number: , Supplement: ,
Publisher American Society for Microbiology (ASM)
Reviewing status Peer reviewed
Institute(s) Institute of Virology (VIRO)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Immune Response and Infection
PSP Element(s) G-502700-001
PubMed ID 16611901
DOI 10.1128/JVI.80.9.4415-4421.2006
WOS ID 000236980000022
Scopus ID 33646185910
Erfassungsdatum 2006-12-31
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