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Warren, M.V.* ; Studley, M.L.* ; Dubus, P.* ; Fiette, L.* ; Rozell, B.* ; Quintanilla-Martinez, L. ; Raspa, M.* ; Breuer, M.* ; Song, J.Y.* ; Gates, H.* ; Brown, S.D.* ; Schofield, P.N.*

An impending crisis in the provision of histopathology expertise for mouse functional genomics.

J. Pathol. 217, 4-13 (2009)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
The generation of new mouse models of human disease is accelerating rapidly, due to the completion of whole-genome sequencing efforts and technological advances in the manipulation of the mouse genome. We sought to investigate manpower issues in the provision of histopathology expertise for mouse functional genomics and compared this to the perceived demand from principal investigators (PIs). Through the European Commission (EC)-funded PRIME pathology training initiative, two questionnaires were devised to collect information from pathologists and EC-funded PIs on the current provision of mouse histopathology expertise in Europe and the demands for this service. We find that pathological analysis is being performed almost exclusively by professionally qualified pathologists, generally employed in clinical diagnostic posts, where the work is undertaken as collaboration outside of their contractual commitments but without previous training in veterinary or comparative pathology. The results indicate that there is a lack of both trainees and provision of specialist training in this field. Unsurprisingly, the availability of diagnostic expertise and advice falls far short of the number of genetically engineered mice (GEM) being generated for analysis. We analyse these results with reference to previous studies and discuss solutions for the future recruitment, training and funding for pathologists in mouse functional genomics in Europe.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords pathology; manpower; questionnaire survey; training; recruitment; mouse functional genomics; phenotyping; PRIME; European Commission; funding
ISSN (print) / ISBN 0022-3417
e-ISSN 1096-9896
Journal Journal of Pathology, The
Quellenangaben Volume: 217, Issue: 1, Pages: 4-13 Article Number: , Supplement: ,
Publisher Wiley
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Pathology (PATH)