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Brand, P. ; Meyer, T.* ; Sommerer, K.* ; Weber, N.* ; Scheuch, G.*

Alveolar deposition of monodisperse aerosol particles in the lung of patients with chronic obstructive pulmonary disease.

Exp. Lung Res. 28, 39-54 (2002)

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Open Access Green as soon as Postprint is submitted to ZB.

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Knowledge about the regional deposition of aerosol particles is essential in order to perform efficient inhalation therapy or to minimize health risks due to environmental or occupational aerosol particles. In this study, 2 techniques were used to measure thoracic deposition and to differentiate between bronchial and alveolar deposition. The first technique was the clearance-derived regional deposition (CRD) technique and the second the single-breath regional deposition (SBRD) technique. Deposition was measured in 12 patients with alpha1-antitrypsin deficiency and symptoms of moderate to severe chronic obstructive pulmonary disease (COPD) using monodisperse test particles with aerodynamic diameters of 2, 3, and 4 microm. In CRD, the kinetic of particle clearance within the first 24 hours after inhalation was used to determine bronchial and alveolar deposition. In SBRD, the longitudinal distribution of deposited inert test particles was used to calculate the particle fraction deposited within and distal to the dead space. Both techniques delivered very similar mean values for total and alveolar deposition. Due to controlled slow and deep inhalations, alveolar deposition was as much as 50%. Therefore, SBRD can be considered as an easy tool to study alveolar deposition in patients.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords alveolar deposition; clearance; COPD; distribution of deposition

ISSN (print) / ISBN 0190-2148

e-ISSN 1521-0499

Journal Experimental Lung Research

Quellenangaben Volume: 28, Issue: 1, Pages: 39-54

Publisher Informa Healthcare

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Lung Biology (LHI)