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Schmid, O. ; Möller, W. ; Semmler-Behnke, M. ; Ferron, G.A. ; Karg, E.W. ; Lipka, J. ; Schulz, S. ; Kreyling, W.G. ; Stöger, T.

Dosimetry and toxicology of inhaled ultrafine particles.

Biomarkers 14, (Suppl.1), 67-73 (2009)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Both epidemiological and toxicological studies indicate that inhalation and subsequent deposition of air borne particles into the lungs have adverse health effects. Recently, the ultrafine particle (UfP) fraction (diameter < 100nm) has received particular attention, as their small size may lead to more toxic proper ties. In this study we summarize the current knowledge on the dosimetry of inhaled particles (including UfPs) with a focus on recent data on translocation of UfPs into secondary target organs (such as brain and heart) suggesting that the lifetime dose of ambient UfPs in secondary target organs is about 1011 particles. Furthermore, we highlight the main pathways of particle induced toxicity and the reasons for the potentially higher toxicity of UfPs. Finally, we discuss recent evidence indicating that (BET) surface area is the single most relevant dose metric for the toxicity of UfPs, which has important implications for regulatory measures on the toxicity of ambient and engineered particles.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Oxidative stress; lung; ROS; nanoparticle toxicity; BET surface area; particle toxicity; insoluble iridium particles; human respiratory-tract; in-vivo; oxidative stress; air-pollution; surface-area; utah valley; extrapulmonary translocation; particulate matter; organic-compounds
ISSN (print) / ISBN 1354-750X
e-ISSN 1366-5804
Journal Biomarkers
Quellenangaben Volume: 14, Issue: SUPPL.1, Pages: 67-73, Article Number: , Supplement: (Suppl.1)
Publisher Informa Healthcare
Publishing Place Abingdon
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Lung Biology (LHI)
Lung Health and Immunity (LHI)
CCG Inflammatory Lung Diseases (CPC-KEL)
Cooperation Group Comprehensive Molecular Analytics (CMA)