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Harold, D.* ; Abraham, R.* ; Hollingworth, P.* ; Sims, R.* ; Gerrish, A.* ; Hamshere, M.L.* ; Pahwa, J.S.* ; Moskvina, V.* ; Dowzell, K.* ; Williams, A.* ; Jones, N.* ; Thomas, C.* ; Stretton, A.* ; Morgan, A.R.* ; Lovestone, S.* ; Powell, J.* ; Proitsi, P.* ; Lupton, M.K.* ; Brayne, C.* ; Rubinsztein, D.C.* ; Gill, M.* ; Lawlor, B.* ; Lynch, A.* ; Morgan, K.* ; Brown, K.S.* ; Passmore, P.A.* ; Craig, D.* ; Guinness, B.* ; Todd, S.* ; Holmes, C.* ; Mann, D.* ; Smith, A.D.* ; Love, S.* ; Kehoe, P.G.* ; Hardy, J.* ; Mead, S.* ; Fox, N.* ; Rossor, M.* ; Collinge, J.* ; Maier, W.* ; Jessen, F.* ; Schürmann, B.* ; van den Bussche, H.* ; Heuser, I.* ; Kornhuber, J.* ; Wiltfang, J.* ; Dichgans, M.* ; Frölich, L.* ; Hampel, H.* ; Hüll, M.* ; Rujescu, D.* ; Goate, A.M.* ; Kauwe, J.S.K.* ; Cruchaga, C.* ; Nowotny, P.* ; Morris, J.C.* ; Mayo, K.* ; Sleegers, K.* ; Bettens, K.* ; Engelborghs, S.* ; de Deyn, P.P.* ; van Broeckhoven, C.* ; Livingston, G.* ; Bass, N.J.* ; Gurling, H.* ; McQuillin, A.* ; Gwilliam, R.* ; Deloukas, P.* ; Al-Chalabi, A.* ; Shaw, C.E.* ; Tsolaki, M.* ; Singleton, A.B.* ; Guerreiro, R.* ; Mühleisen, T.W.* ; Nöthen, M.M.* ; Moebus, S.* ; Jöckel, K.-H.* ; Klopp, N. ; Wichmann, H.-E. ; Carrasquillo, M.M.* ; Pankratz, V.S.* ; Younkin, S.G.* ; Holmans, P.A.* ; O'Donovan, M.* ; Owen, M.J.* ; Williams, J.*

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.

Nat. Genet. 41, 1088-1093 (2009)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 cases and 7,848 controls), we replicated the established association with the apolipoprotein E (APOE) locus (most significant SNP, rs2075650, P = 1.8 x 10(-157)) and observed genome-wide significant association with SNPs at two loci not previously associated with the disease: at the CLU (also known as APOJ) gene (rs11136000, P = 1.4 x 10(-9)) and 5' to the PICALM gene (rs3851179, P = 1.9 x 10(-8)). These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86).
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 41, Issue: 10, Pages: 1088-1093 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)