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Open Access Green as soon as Postprint is submitted to ZB.
Imaging of molecular probe activity with Born-normalized fluorescence optical projection tomography.
Opt. Lett. 35, 1088-1090 (2010)
Optical projection tomography is a new ex vivo imaging technique that allows imaging of whole organs in three dimensions at high spatial resolutions. In this Letter we demonstrate its capability to tomographically visualize molecular activity in whole organs of mice. In particular, eosinophil activity in asthmatic lungs is resolved using a Born-normalized fluorescence optical projection tomography and employing a near-IR molecular probe. The possibility to achieve molecularly sensitive imaging contrast in optical projection tomography by means of targeted and activatable imaging reporter agents adds a new range of capabilities for investigating molecular signatures of pathophysiological processes and a wide variety of diseases and their development.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
In vivo
Language
english
Publication Year
2010
HGF-reported in Year
2010
ISSN (print) / ISBN
0146-9592
e-ISSN
1539-4794
Journal
Optics Letters
Quellenangaben
Volume: 35,
Issue: 7,
Pages: 1088-1090
Publisher
Optical Society of America (OSA)
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s)
30205 - Bioengineering and Digital Health
Research field(s)
Enabling and Novel Technologies
PSP Element(s)
G-505500-001
PubMed ID
20364226
Erfassungsdatum
2010-06-09