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Ale, A.B.F. ; Schulz, R.B. ; Sarantopoulos, A. ; Ntziachristos, V.

Imaging performance of a hybrid X-ray computed tomography-fluorescence molecular tomography system using priors.

Med. Phys. 37, 1976-1986 (2010)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Methods: Approaches that incorporate structural prior information were included in the inverse problem by adding a penalty term to the minimization function utilized for image reconstructions. Results were compared as to their performance with simulated and experimental data from a lung inflammation animal model and against the inversions achieved when not using priors. Results: The importance of using priors over stand-alone inversions is also showcased with high spatial sampling simulated and experimental data. The approach of optimal performance in resolving fluorescent biodistribution in small animals is also discussed. Conclusions: Inclusion of prior information from x-ray CT data in the reconstruction of the fluorescence biodistribution leads to improved agreement between the reconstruction and validation images for both simulated and experimental data.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Biomedical optical imaging; CCD image sensors; Computerised tomography; Fluorescence; Image reconstruction; Inverse problems; Lung; Medical image processing; Optical tomography; Physiological models
ISSN (print) / ISBN 0094-2405
e-ISSN 1522-8541
Journal Medical Physics
Quellenangaben Volume: 37, Issue: 5, Pages: 1976-1986 Article Number: , Supplement: ,
Publisher American Institute of Physics (AIP)
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)