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Wong, P. ; Frishman, D.

Designability and Disease.

In:. Berlin [u.a.]: Springer, 2008. 491-504 (Methods Mol. Biol. ; 484)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Structural designability is the number of ways it is possible to encode for structure. A protein’s designability has been equated with the size of sequence space encoding for the protein’s structure, a measure that reflects the structure’s robustness to mutation. Current evidence suggests that designability is fundamental to our understanding of the evolvability and distribution of structures in nature and is a significant factor associated with human disease. Here, we describe definitions and principles underlying the concept of designability and discuss its relation to disease.
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Publication type Article: Edited volume or book chapter
Editors Chen, E.H.*
Corresponding Author
Keywords Protein evolution; structure classification; genome analysis; disease
ISSN (print) / ISBN 1064-3745
e-ISSN 1940-6029
ISBN 978-1-58829-971-0
Journal Methods in Molecular Biology
Quellenangaben Volume: 484, Issue: , Pages: 491-504 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Berlin [u.a.]
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Bioinformatics and Systems Biology (IBIS)