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Open Access Green as soon as Postprint is submitted to ZB.
Designability and Disease.
In:. Berlin [u.a.]: Springer, 2008. 491-504 (Methods Mol. Biol. ; 484)
Structural designability is the number of ways it is possible to encode for structure. A protein’s designability has been equated with the size of sequence space encoding for the protein’s structure, a measure that reflects the structure’s robustness to mutation. Current evidence suggests that designability is fundamental to our understanding of the evolvability and distribution of structures in nature and is a significant factor associated with human disease. Here, we describe definitions and principles underlying the concept of designability and discuss its relation to disease.
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Publication type
Article: Edited volume or book chapter
Editors
Chen, E.H.*
Keywords
Protein evolution; structure classification; genome analysis; disease
ISSN (print) / ISBN
1064-3745
e-ISSN
1940-6029
ISBN
978-1-58829-971-0
Journal
Methods in Molecular Biology
Quellenangaben
Volume: 484,
Pages: 491-504
Publisher
Springer
Publishing Place
Berlin [u.a.]
Reviewing status
Peer reviewed