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Open Access Green as soon as Postprint is submitted to ZB.
c-Myc overexpression promotes a germinal center-like program in Burkitt's lymphoma.
Oncogene 29, 888-897 (2010)
The germinal center (GC) reaction has a pivotal function in human B-cell lymphomagenesis. Genetic aberrations occurring during somatic hypermutation and class switch recombination deregulate key factors controlling B-cell physiology and proliferation. Several human lymphoma entities are characterized by a constitutive GC phenotype and ongoing somatic hypermutation, but the molecular basis for this phenomenon is only partly understood. We have investigated the reasons for a constitutive GC-like program in Burkitt's lymphoma cells. Here, overexpression of c-Myc leads to a centroblast phenotype, promotes high constitutive expression of the key GC factors Bcl-6, E2A and activation-induced cytidine deaminase and contributes to proliferation and somatic hypermutation. Our findings elucidate how the activity of a pivotal transcription factor may freeze B-cell lymphoma cells in a constitutive GC-like state that is even maintained at an extrafollicular location.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
somatic hypermutation; germinal center; Burkitt's lymphoma; c-Myc
ISSN (print) / ISBN
0950-9232
e-ISSN
0950-9232
Journal
Oncogene
Quellenangaben
Volume: 29,
Issue: 6,
Pages: 888-897
Publisher
Nature Publishing Group
Reviewing status
Peer reviewed