Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
DOI
 |
|
Open Access Green as soon as Postprint is submitted to ZB.
From more to less than Haber's law.
Environ. Toxicol. Pharmacol. 11, 227-232 (2002)
We show how reformulating a first-order response theory with respect to both toxicant concentration and exposure time, in terms of relative instead of absolute increments, leads to a generalized version of Haber's law and to a combined sigmoid model for concentration and time response, derived on analytical rather than empirical grounds. More general presuppositions of Haber's law (without assuming sigmoid response) are briefly discussed. The relative intensities of time response and concentration response are measured by a single dimensionless parameter, characterizing each quadruple {toxicant, route, species, adverse effect}. Cross-species and cross-toxicant variability of this parameter is discussed and illustrated by new findings on algae and Daphniae exposed to selected inorganic and organic pollutants.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Time-dose additivity; Endpoint conversions; Haber's law; Pentachlorophenol; Daphnia magna; Scenedesmus subspicatus
ISSN (print) / ISBN
1382-6689
e-ISSN
1872-7077
Quellenangaben
Volume: 11,
Issue: 3-4,
Pages: 227-232
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Ecological Chemistry (IOEC)
Institute of Groundwater Ecology (IGOE)
Institute of Molecular Toxicology and Pharmacology (TOXI)
Institute of Groundwater Ecology (IGOE)
Institute of Molecular Toxicology and Pharmacology (TOXI)