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Razansky, D. ; Ntziachristos, V.

Fluorescence Molecular Tomography using a-priori Photoacoustic data.

Proc. SPIE 6856:685617 (2008)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
We present the first hybrid photoacoustic fluorescence molecular tomography system, capable of three-dimensional imaging of both fluorochrome and chromophore distributions in highly scattering and absorbing tissue. Quantitative three-dimensional maps of optical absorption coefficient are acquired using photoacoustic tomography. The reconstructed absorption data is fed into the Fluorescence Molecular Tomography inversion scheme in order to improve its accuracy and quatification capabilities in the presence of strong and distributed absorbers that are expected to bias stand-alone fluorescence reconstructions. At all, having both techniques in one hybrid modality yields a system that combines high molecular specificity and targeting flexibility of fluorescent imaging and high spatial resolution functional information obtained via photo-acoustic images.
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Publication type Article: Journal article
Document type Scientific Article
Editors Oraevsky, A.A.* ; Wang, L.V.*
ISSN (print) / ISBN 0277-786X
e-ISSN 1996-756X
Conference Title Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acoust
Journal Proceedings of SPIE
Quellenangaben Volume: 6856, Issue: , Pages: , Article Number: 685617 Supplement: ,
Series Proceedings of SPIE
Publisher SPIE
Publishing Place Bellingham, WA
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)