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Open Access Green as soon as Postprint is submitted to ZB.
Multi-spectral photo-acoustic molecular tomography resolves fluorochrome distribution with high resolution and sensitivity in small animals.
Proc. SPIE 6856:685613 (2008)
Current non-invasive imaging methods of fluorescent molecular probes in the visible and near-infrared suffer from low spatial resolution as a result of rapid light diffusion in biological tissues. We show that three-dimensional distribution of fluorochromes deep in small animals can be resolved with below 25 femtomole sensitivity and 150 microns spatial resolution by means of multi-spectral photo-acoustic molecular tomography. The low sensitivity limit of the method is enabled by using the highly resonant absorption spectrum of a commonly used near-infrared fluorescent molecular probe Alexa Fluor 750 in order to acquire differential images at multiple wavelengths with tomographic topology suitable for whole-body small animal imaging.
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Publication type
Article: Journal article
Document type
Scientific Article
Editors
Oraevsky, A.A.* ; Wang, L.V.*
ISSN (print) / ISBN
0277-786X
e-ISSN
1996-756X
Conference Title
Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acoust
Journal
Proceedings of SPIE
Quellenangaben
Volume: 6856,
Article Number: 685613
Series
Proceedings of SPIE
Publisher
SPIE
Publishing Place
Bellingham, WA
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)