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Open Access Green as soon as Postprint is submitted to ZB.
Epigenetic regulation of neurogenesis in the adult hippocampus.
Heredity 105, 122-134 (2010)
The dentate gyrus of the hippocampus is an exception to a 'neurogenesis-unfriendly' environment of the adult brain. New functional neurons generated in this region contribute to learning and mood regulation, and thus represent a unique form of neural plasticity. The rate of hippocampal neurogenesis significantly changes on physiological or pathological influences, such as physical activity, environmental enrichment, stress, and aging. We suggest that epigenetic mechanisms could be sensors of environmental changes and fine modulators of adult hippocampal neurogenesis. Here, we examine the role of DNA methylation and methylation of core histones mediated by the Polycomb and Trithorax complexes in the regulation of adult neurogenesis. Given the recent surprising discovery of dynamic and reversible DNA methylation in the hippocampus, we speculate regarding its regulation and its role in adult neurogenesis.
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Publication type
Article: Journal article
Document type
Review
Keywords
Adult neurogenesis; Dynamic methylation; Histone methylation; DNA methylation; Epigenetic modifications; Hippocampus
ISSN (print) / ISBN
0018-067X
e-ISSN
1365-2540
Journal
Heredity
Quellenangaben
Volume: 105,
Issue: 1,
Pages: 122-134
Publisher
Nature Publishing Group
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Developmental Genetics (IDG)