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Increased Interleukin 4 (IL-4) Receptor Expression and IL-4-Induced Decrease in IL-12 Production by Langerhans Cells Infected with Leishmania major.
Infect. Immun. 70, 1627-1630 (2002)
Langerhans cells (LC) take up Leishmania major and are critical for the induction of the parasite-specific T-cell response. Their functional activities are regulated by cytokines. We analyzed whether infection of LC with L. major modulates the expression of their cytokine receptors. The expression of the interleukin 4 (IL-4) receptor was increased on infected LC from susceptible mice but not on those from resistant mice. Moreover, IL-4 treatment strongly decreased the lipopolysaccharide-induced IL-12 response of infected LC from susceptible mice. This modulation of IL-4 receptor expression and IL-12 production by infection of LC with Leishmania may contribute to the development of Th2 cells and to susceptibility to infection.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
CD4(+) T-CELLS; DENDRITIC CELLS; CUTANEOUS LEISHMANIASIS; BALB/C MICE; MACROPHAGES; AMASTIGOTES; SUSCEPTIBILITY; PROMASTIGOTES; INITIATION; ACTIVATION
Language
english
Publication Year
2002
HGF-reported in Year
0
ISSN (print) / ISBN
0019-9567
e-ISSN
1098-5522
Journal
Infection and Immunity
Quellenangaben
Volume: 70,
Pages: 1627-1630
Publisher
American Society for Microbiology (ASM)
Reviewing status
Peer reviewed
Institute(s)
CCG Tumor Therapy with Hyperthermia (IMI-KTH)
POF-Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Immune Response and Infection
PSP Element(s)
G-521100-001
Erfassungsdatum
2002-10-27