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Huth, C. ; Illig, T. ; Herder, C.* ; Gieger, C. ; Grallert, H. ; Vollmert, C. ; Rathmann, W.* ; Hamid, Y.H.* ; Pedersen, O.* ; Hansen, T.* ; Thorand, B. ; Meisinger, C. ; Döring, A. ; Klopp, N. ; Gohlke, H. ; Lieb, W.* ; Hengstenberg, C.* ; Lyssenko, V.* ; Groop, L.* ; Ireland, H.* ; Stephens, J.W.* ; Wernstedt Asterholm, I.* ; Jansson, J.-O.* ; Boeing, H.* ; Möhlig, M.* ; Stringham, H.M.* ; Boehnke, M.* ; Tuomilehto, J.* ; Fernandez-Real, J.-M.* ; Lopez-Bermejo, A.* ; Gallart, L.* ; Vendrell, J.* ; Humphries, S.E.* ; Kronenberg, F.* ; Wichmann, H.-E. ; Heid, I.M.

Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index.

Ann. Med. 41, 128-138 (2009)

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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.

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Background. Several studies have investigated associations between the -174GC single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results. Aims. This joint analysis aimed to clarify whether IL6 -174GC was associated with glucose and circulating interleukin-6 concentrations as well as body mass index (BMI). Methods. Individual-level data from all studies of the IL6-T2DM consortium on Caucasian subjects with available BMI were collected. As study-specific estimates did not show heterogeneity (P0.1), they were combined by using the inverse-variance fixed-effect model. Results. The main analysis included 9440, 7398, 24,117, or 5659 non-diabetic and manifest T2DM subjects for fasting glucose, 2-hour glucose, BMI, or circulating interleukin-6 levels, respectively. IL6 -174 C-allele carriers had significantly lower fasting glucose (-0.091 mmol/L, P=0.014). There was no evidence for association between IL6 -174GC and BMI or interleukin-6 levels, except in some subgroups. Conclusions. Our data suggest that C-allele carriers of the IL6 -174GC polymorphism have lower fasting glucose levels on average, which substantiates previous findings of decreased T2DM risk of these subjects.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Blood glucose; body mass index; diabetes mellitus type 2; genes; inflammation mediators; interleukin-6; intermediate phenotype; meta-analysis; molecular epidemiology; single nucleotide polymorphism; g/c promoter polymorphism; type-2 diabetes-mellitus; myocardial-infarction; gene promoter; risk-factors; plasma interleukin-6; metabolic syndrome; metaanalysis; obesity; cohort

ISSN (print) / ISBN 0785-3890

e-ISSN 1365-2060

Journal Annals of Medicine

Quellenangaben Volume: 41, Issue: 2, Pages: 128-138

Publisher Informa Healthcare

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Epidemiology (EPI)