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Open Access Green as soon as Postprint is submitted to ZB.
Mechanistic modelling in large case-control studies of lung cancer risk from smoking.
Stat. Med. 21, 3055-3070 (2002)
The two-step clonal expansion (TSCE) model is applied to large case-control studies, frequency matched for age, which allow estimation of the RR of lung tumour risk caused by smoking. For estimating background hazard rates, mortality data from the study areas are used to supplement the case-control data. Two approaches are used to analyse the data, based on the unconditional and the conditional likelihoods. They are demonstrated to give nearly identical results. Some model diagnostics are performed and demonstrate a good model fit. Our results indicate that smoking acts on the promotion and transformation parameters, but not on the initiation parameter of the TSCE model. The fitted relative risk of current smokers peaks between ages 50 and 60 years. The relative risk of male ex-smokers decreases strongly with time since end of exposure, but does not reach the risk of non-smokers, and does not decrease as much as for female ex-smokers.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
mechanistic models; two-step clonal expansion model; frequency matched case-control study; smoking; unconditional likelihood; conditional likelihood
Language
english
Publication Year
2002
HGF-reported in Year
0
ISSN (print) / ISBN
0277-6715
e-ISSN
1097-0258
Journal
Statistics in Medicine
Quellenangaben
Volume: 21,
Pages: 3055-3070
Publisher
Wiley
Reviewing status
Peer reviewed
Institute(s)
Institute of Radiation Protection (ISS)
Institute of Epidemiology (EPI)
Institute of Epidemiology (EPI)
POF-Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Radiation Sciences
PSP Element(s)
G-501100-004
G-503900-002
G-503900-002
Erfassungsdatum
2002-10-24