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Petroff, B.K.* ; Gao, X.* ; Ohshima, K.-I.* ; Son, D.-S.* ; Roby, K.F.* ; Rozman, K.K. ; Watanabe, G.* ; Taya, K.* ; Terranova, P.F.*

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on serum inhibin concentrations and inhibin immunostaining during follicular development in female Spraque-Dawley rats.

Reprod. Toxicol. 16, 97-105 (2002)

Open Access Green as soon as Postprint is submitted to ZB.

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Intact and hypophysectomized immature rats were pretreated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; 0 or 32 mug/kg p.o.) and sacrificed throughout synchronized follicular development (0, 12, 24, 48, and 72 It after equine chorionic gonadotropin, eCG). TCDD administration to intact rats resulted in a premature elevation of serum FSH and LH by 12 h post-eCG. In intact rats pretreated with TCDD, the intensity of ovarian immunoreactivity for inhibin and the number of ovarian follicles staining for inhibin in midsaggital ovarian sections were decreased at the time of eCG administration (24 It post-TCDD) in comparison to controls. However, this decreased ovarian staining for inhibin was not associated with alterations in serum inhibin concentrations. Serum inhibin was suppressed in TCDD-treated rats when compared to intact controls only at 24 h post-eCG. Hypophysectomized animals exhibited no effect of TCDD on serum inhibin at any timepoint but did have decreased estradiol concentrations during follicular development. In summary, TCDD reduced serum concentrations of inhibin after the premature increases in FSH and LH suggesting that inhibin is not important in the initial elevation of FSH following exposure to TCDD.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords GONADOTROPIN-PRIMED RAT; IN-UTERO; LACTATIONAL EXPOSURE; OVULATION MODEL; CYCLIC HAMSTER; ESTROUS-CYCLE; HOLTZMAN RATS; STEROIDOGENESIS; MODULATION; ESTRADIOL

ISSN (print) / ISBN 0890-6238

e-ISSN 0890-6238

Journal Reproductive Toxicology

Quellenangaben Volume: 16, Pages: 97-105

Publisher Elsevier

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Molecular Toxicology and Pharmacology (TOXI)