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Open Access Green as soon as Postprint is submitted to ZB.
Simulation of DNA Damage after Proton and Low Let Irradiation.
Radiat. Prot. Dosim. 99, 99-102 (2002)
A module for proton track structure simulation in liquid water was implemented in the biophysical model PARTRAC. Simulated tracks of energy deposition events from the radiation under investigation were superimposed on a higher-order DNA target model describing the whole genome inside a human cell. The parameters controlling DNA damage from direct and indirect effects were adapted to agree with yields and pathway contributions derived from gamma ray irradiation experiments. Single and double strand break (DSB) induction Was Simulated for irradiations by protons, photon, and electrons over a wide range of initial energies. The relative biological effectiveness for DSB induction after proton irradiation was found to rise from 1.2 at 5 keV mum(-1) to about 2.5 at 70 keV.mum(-1). About half of this grown resulted from an increased production of DSB clusters associated with Small (< 10 kbp) fragments.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
DOUBLE-STRAND BREAKS; DSB INDUCTION; LIQUID WATER; ELECTRON TRACKS; CROSS-SECTIONS; SINGLE-STRAND; ENERGY; CELLS; DEPENDENCE; PHOTONS
ISSN (print) / ISBN
0144-8420
e-ISSN
1742-3406
Journal
Radiation Protection Dosimetry
Quellenangaben
Volume: 99,
Pages: 99-102
Publisher
Oxford University Press
Publishing Place
Oxford
Reviewing status
Peer reviewed
Institute(s)
Institute of Radiation Protection (ISS)