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Simulation of DNA Damage after Proton and Low Let Irradiation.

Radiat. Prot. Dosim. 99, 99-102 (2002)
Open Access Green as soon as Postprint is submitted to ZB.
A module for proton track structure simulation in liquid water was implemented in the biophysical model PARTRAC. Simulated tracks of energy deposition events from the radiation under investigation were superimposed on a higher-order DNA target model describing the whole genome inside a human cell. The parameters controlling DNA damage from direct and indirect effects were adapted to agree with yields and pathway contributions derived from gamma ray irradiation experiments. Single and double strand break (DSB) induction Was Simulated for irradiations by protons, photon, and electrons over a wide range of initial energies. The relative biological effectiveness for DSB induction after proton irradiation was found to rise from 1.2 at 5 keV mum(-1) to about 2.5 at 70 keV.mum(-1). About half of this grown resulted from an increased production of DSB clusters associated with Small (< 10 kbp) fragments.
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Publication type Article: Journal article
Document type Scientific Article
Keywords DOUBLE-STRAND BREAKS; DSB INDUCTION; LIQUID WATER; ELECTRON TRACKS; CROSS-SECTIONS; SINGLE-STRAND; ENERGY; CELLS; DEPENDENCE; PHOTONS
Language english
Publication Year 2002
HGF-reported in Year 0
ISSN (print) / ISBN 0144-8420
e-ISSN 1742-3406
Quellenangaben Volume: 99, Issue: , Pages: 99-102 Article Number: , Supplement: ,
Publisher Oxford University Press
Publishing Place Oxford
Reviewing status Peer reviewed
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Radiation Sciences
PSP Element(s) G-501100-004
Erfassungsdatum 2002-09-11