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    Simulation of DNA Damage after Proton and Low Let Irradiation.
        
        Radiat. Prot. Dosim. 99, 99-102 (2002)
    
    
	    A module for proton track structure simulation in liquid water was implemented in the biophysical model PARTRAC. Simulated tracks of energy deposition events from the radiation under investigation were superimposed on a higher-order DNA target model describing the whole genome inside a human cell. The parameters controlling DNA damage from direct and indirect effects were adapted to agree with yields and pathway contributions derived from gamma ray irradiation experiments. Single and double strand break (DSB) induction Was Simulated for irradiations by protons, photon, and electrons over a wide range of initial energies. The relative biological effectiveness for DSB induction after proton irradiation was found to rise from 1.2 at 5 keV mum(-1) to about 2.5 at 70 keV.mum(-1). About half of this grown resulted from an increased production of DSB clusters associated with Small (< 10 kbp) fragments.
	
	
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        Publication type
        Article: Journal article
    
 
    
        Document type
        Scientific Article
    
 
     
    
    
        Keywords
        DOUBLE-STRAND BREAKS; DSB INDUCTION; LIQUID WATER; ELECTRON TRACKS; CROSS-SECTIONS; SINGLE-STRAND; ENERGY; CELLS; DEPENDENCE; PHOTONS
    
 
     
    
    
        Language
        english
    
 
    
        Publication Year
        2002
    
 
     
    
        HGF-reported in Year
        0
    
 
    
    
        ISSN (print) / ISBN
        0144-8420
    
 
    
        e-ISSN
        1742-3406
    
 
    
     
     
	     
	 
	 
    
        Journal
        Radiation Protection Dosimetry
    
 
	
    
        Quellenangaben
        
	    Volume: 99,  
	    
	    Pages: 99-102 
	    
	    
	
    
 
    
         
        
            Publisher
            Oxford University Press
        
 
        
            Publishing Place
            Oxford
        
 
	
         
         
         
         
         
	
         
         
         
    
         
         
         
         
         
         
         
    
        Reviewing status
        Peer reviewed
    
 
    
        Institute(s)
        Institute of Radiation Protection (ISS)
    
 
    
        POF-Topic(s)
        30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
    
 
    
        Research field(s)
        Radiation Sciences
    
 
    
        PSP Element(s)
        G-501100-004
    
 
     
     	
    
        Erfassungsdatum
        2002-09-11