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Open Access Green as soon as Postprint is submitted to ZB.
Simulation of 125I induced DNA strand breaks in a CAP-DNA complex.
Radiat. Prot. Dosim. 99, 109-112 (2002)
The E. coli catabolite gene activator protein (CAP)-DNA complex with I-125 located at the position of the H5 atom of the cytosine near the centre was incorporated into the PARTRAC track structure code. DNA strand breaks due to irradiation were calculated by track structure and radical attack simulations strand breaks due to neutralisation of the highly charged Te-125 ion were derived from a semi-empirical distribution. According to the calculations, the neutralisation effect dominates the strand breakage frequency at 2 bases away front the I-125 decay site on both strands. The first breakage distribution counted from a P-32 labelled end on the strand with I-125 agreed well with experimental data. but on the opposite strand. the calculated distribution is more concentrated around the decay site and its yield is about 20% larger than the measured data.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
MONTE-CARLO SIMULATION; SYNTHETIC OLIGODEOXYNUCLEOTIDE; LIQUID WATER; DECAY; IRRADIATION; MODELS
Language
english
Publication Year
2002
HGF-reported in Year
0
ISSN (print) / ISBN
0144-8420
e-ISSN
1742-3406
Journal
Radiation Protection Dosimetry
Quellenangaben
Volume: 99,
Pages: 109-112
Publisher
Oxford University Press
Publishing Place
Oxford
Reviewing status
Peer reviewed
Institute(s)
Institute of Radiation Protection (ISS)
POF-Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Radiation Sciences
PSP Element(s)
G-501100-004
Erfassungsdatum
2002-10-16