PuSH - Publication Server of Helmholtz Zentrum München: Intravascular near-infrared fluorescence molecular imaging of atherosclerosis: Toward coronary arterial visualization of biologically high-risk plaques.

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Calfon, M.A.* ; Vinegoni, C.* ; Ntziachristos, V. ; Jaffer, F.A.*

Intravascular near-infrared fluorescence molecular imaging of atherosclerosis: Toward coronary arterial visualization of biologically high-risk plaques.

J. Biomed. Opt. 15:011107 (2010)

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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.

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New imaging methods are urgently needed to identify high-risk atherosclerotic lesions prior to the onset of myocardial infarction, stroke, and ischemic limbs. Molecular imaging offers a new approach to visualize key biological features that characterize high-risk plaques associated with cardiovascular events. While substantial progress has been realized in clinical molecular imaging of plaques in larger arterial vessels (carotid, aorta, iliac), there remains a compelling, unmet need to develop molecular imaging strategies targeted to high-risk plaques in human coronary arteries. We present recent developments in intravascular near-IR fluorescence catheter-based strategies for in vivo detection of plaque inflammation in coronary-sized arteries. In particular, the biological, light transmission, imaging agent, and engineering principles that underlie a new intravascular near-IR fluorescence sensing method are discussed. Intravascular near-IR fluorescence catheters appear highly translatable to the cardiac catheterization laboratory, and thus may offer a new in vivo method to detect high-risk coronary plaques and to assess novel atherosclerosis biologics.

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