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Li, H.* ; Gan, W.* ; Lu, L.* ; Dong, X.* ; Han, X.* ; Hu, C.* ; Yang, Z.* ; Sun, L.* ; Bao, W.* ; Li, P.* ; He, M.* ; Wang, Y.* ; Zhu, J.* ; Ning, Q.* ; Tang, Y.* ; Zhang, R.* ; Wen, J.* ; Wang, D.* ; Zhu, X.* ; Guo, K.* ; Zuo, X.* ; Guo, X.* ; Yang, H.* ; Zhou, X.* ; DIAGRAM Consortium (Huth, C. ; Grallert, H. ; Gieger, C. ; Klopp, N. ; Petersen, A.-K. ; Thorand, B. ; Wichmann, H.-E. ; Illig, T. ; Meitinger, T.) ; AGEN-T2D Consortium (*) ; Zhang, X.* ; Qi, L.* ; Loos, R.J.* ; Hu, F.B.* ; Wu, T.* ; Liu, Y.* ; Liu, L.* ; Hu, R.* ; Jia, W.* ; Ji, L.* ; Li, Y.* ; Lin, X.*

A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.

Diabetes 62, 291-298 (2013)
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Substantial progress has been made in identification of type 2 diabetes (T2D) risk loci in the past few years, but our understanding of the genetic basis of T2D in ethnically diverse populations remains limited. We performed a genome-wide association study and a replication study in Chinese Hans comprising 8,569 T2D case subjects and 8,923 control subjects in total, from which 10 single nucleotide polymorphisms were selected for further follow-up in a de novo replication sample of 3,410 T2D case and 3,412 control subjects and an in silico replication sample of 6,952 T2D case and 11,865 control subjects. Besides confirming seven established T2D loci (CDKAL1, CDKN2A/B, KCNQ1, CDC123, GLIS3, HNF1B, and DUSP9) at genome-wide significance, we identified two novel T2D loci, including G-protein-coupled receptor kinase 5 (GRK5) (rs10886471: P = 7.1 × 10(-9)) and RASGRP1 (rs7403531: P = 3.9 × 10(-9)), of which the association signal at GRK5 seems to be specific to East Asians. In nondiabetic individuals, the T2D risk-increasing allele of RASGRP1-rs7403531 was also associated with higher HbA(1c) and lower homeostasis model assessment of β-cell function (P = 0.03 and 0.0209, respectively), whereas the T2D risk-increasing allele of GRK5-rs10886471 was also associated with higher fasting insulin (P = 0.0169) but not with fasting glucose. Our findings not only provide new insights into the pathophysiology of T2D, but may also shed light on the ethnic differences in T2D susceptibility.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2013
HGF-reported in Year 2013
ISSN (print) / ISBN 0012-1797
e-ISSN 1939-327X
Journal Diabetes
Quellenangaben Volume: 62, Issue: 1, Pages: 291-298 Article Number: , Supplement: ,
Publisher American Diabetes Association
Publishing Place Alexandria, VA.
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Research Unit Molecular Epidemiology (AME)
Institute of Genetic Epidemiology (IGE)
POF-Topic(s) 30202 - Environmental Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
90000 - German Center for Diabetes Research
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-002
G-504200-002
G-504100-001
G-501900-401
PubMed ID 22961080
DOI 10.2337/db12-0454
Erfassungsdatum 2013-02-04
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