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Kugler, J.E.* ; Horsch, M. ; Huang, D.* ; Furusawa, T.* ; Rochman, M.* ; Garrett, L. ; Becker, L. ; Bohla, A. ; Hölter, S.M. ; Prehn, C. ; Rathkolb, B. ; Rácz, I.* ; Aguilar-Pimentel, J.A. ; Adler, T. ; Adamski, J. ; Beckers, J. ; Busch, D.H.* ; Eickelberg, O. ; Klopstock, T.* ; Ollert, M.* ; Stöger, T. ; Wolf, E.* ; Wurst, W. ; Yildirim, A.Ö. ; Zimmer, A.* ; Gailus-Durner, V. ; Fuchs, H. ; Hrabě de Angelis, M. ; Garfinkel, B.* ; Orly, Y.* ; Ovcharenko, I.* ; Bustin, M.*

High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner.

J. Biol. Chem. 288, 16690-16703 (2013)
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The nuclei of most vertebrate cells contain members of the high mobility group N (HMGN) protein family which bind specifically to nucleosome core particles and affect the structure and function of chromatin, including transcription. Here we study the biological role of this protein family by systematic analysis of phenotypes and tissue transcription profiles in mice lacking functional HMGN variants. Phenotypic analysis of Hmgn1-/-, Hmgn3-/-, and Hmgn5-/- mice and their wild type littermates with a battery of standardized tests uncovered variant-specific abnormalities. Gene expression analysis of four different tissues in each of the Hmgn-/- lines reveals very little overlap between the genes affected by the specific variants in the different tissues. Pathway analysis revels that loss of an HMGN variant affects subtly the expression of numerous genes in specific biological processes. We conclude that within the biological framework of an entire organism, HMGNs modulate the fidelity of the cellular transcriptional profile in a tissue- and HMGN variant-specific manner.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Hmg Chromosomal-proteins ; Histone H1 ; Binding-protein ; Chromatin-structure ; Ionizing-radiation ; Tribbles Homolog ; Living Cells ; Gene ; Expression ; Mouse
Language english
Publication Year 2013
HGF-reported in Year 2013
ISSN (print) / ISBN 0021-9258
e-ISSN 1083-351X
Journal Journal of Biological Chemistry, The
Quellenangaben Volume: 288, Issue: 23, Pages: 16690-16703 Article Number: , Supplement: ,
Publisher American Society for Biochemistry and Molecular Biology
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)
Molekulare Endokrinologie und Metabolismus (MEM)
CF Metabolomics & Proteomics (CF-MPC)
Institute of Developmental Genetics (IDG)
Institute of Lung Health and Immunity (LHI)
POF-Topic(s) 30201 - Metabolic Health
30203 - Molecular Targets and Therapies
90000 - German Center for Diabetes Research
30204 - Cell Programming and Repair
30202 - Environmental Health
Research field(s) Genetics and Epidemiology
Enabling and Novel Technologies
Lung Research
PSP Element(s) G-500600-004
G-500600-003
G-505600-001
G-505700-001
G-501900-063
G-501900-061
G-500500-001
G-500600-001
G-501600-001
G-505000-001
G-505000-007
G-505000-006
PubMed ID 23620591
DOI 10.1074/jbc.M113.463315
WOS ID WOS:000320378900044
Scopus ID 84878750993
Erfassungsdatum 2013-05-02
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