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Jaremek, M. ; Yu, Z. ; Mangino, M.* ; Mittelstraß, K. ; Prehn, C. ; Singmann, P. ; Xu, T. ; Dahmen, N.* ; Weinberger, K.M.* ; Suhre, K. ; Peters, A. ; Döring, A. ; Hauner, H.* ; Adamski, J. ; Illig, T. ; Spector, T.D.* ; Wang-Sattler, R.

Alcohol-induced metabolomic differences in humans.

Transl. Psychiatry 3:e276 (2013)
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Alcohol consumption is one of the world's major risk factors for disease development. But underlying mechanisms by which moderate-to-heavy alcohol intake causes damage are poorly understood and biomarkers are sub-optimal. Here, we investigated metabolite concentration differences in relation to alcohol intake in 2090 individuals of the KORA F4 and replicated results in 261 KORA F3 and up to 629 females of the TwinsUK adult bioresource. Using logistic regression analysis adjusted for age, body mass index, smoking, high-density lipoproteins and triglycerides, we identified 40/18 significant metabolites in males/females with P-values <3.8E-04 (Bonferroni corrected) that differed in concentrations between moderate-to-heavy drinkers (MHD) and light drinkers (LD) in the KORA F4 study. We further identified specific profiles of the 10/5 metabolites in males/females that clearly separated LD from MHD in the KORA F4 cohort. For those metabolites, the respective area under the receiver operating characteristic curves were 0.812/0.679, respectively, thus providing moderate-to-high sensitivity and specificity for the discrimination of LD to MHD. A number of alcohol-related metabolites could be replicated in the KORA F3 and TwinsUK studies. Our data suggests that metabolomic profiles based on diacylphosphatidylcholines, lysophosphatidylcholines, ether lipids and sphingolipids form a new class of biomarkers for excess alcohol intake and have potential for future epidemiological and clinical studies.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Alcohol; Alcoholism; Biomarkers; Gender; Lipids; Metabolomics; Acid Ethyl-esters ; Targeted Metabolomics ; Mass-spectrometry ; Phospholipase-d ; Ethanol Intake ; Risk-factors ; Human Blood ; Rat-brain ; Phosphatidylethanol ; Consumption
Language english
Publication Year 2013
HGF-reported in Year 2013
ISSN (print) / ISBN 2158-3188
e-ISSN 2158-3188
Journal Translational Psychiatry
Quellenangaben Volume: 3, Issue: , Pages: , Article Number: e276 Supplement: ,
Publisher Nature Publishing Group
Reviewing status Peer reviewed
Institute(s) Molekulare Endokrinologie und Metabolismus (MEM)
Research Unit Molecular Epidemiology (AME)
Institute of Bioinformatics and Systems Biology (IBIS)
Institute of Epidemiology (EPI)
Institute of Experimental Genetics (IEG)
POF-Topic(s) 30201 - Metabolic Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30505 - New Technologies for Biomedical Discoveries
30202 - Environmental Health
90000 - German Center for Diabetes Research
Research field(s) Genetics and Epidemiology
Enabling and Novel Technologies
PSP Element(s) G-505600-001
G-504200-003
G-503700-001
G-504000-001
G-501900-061
G-504200-002
G-504090-001
PubMed ID 23820610
DOI 10.1038/tp.2013.55
WOS ID WOS:000327467400001
Scopus ID 84880113662
Erfassungsdatum 2013-07-04
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