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Bamia, C.* ; Halkjaer, J.* ; Lagiou, P.* ; Trichopoulos, D.* ; Tjønneland, A.* ; Berentzen, T.L.* ; Overvad, K.* ; Clavel-Chapelon, F.* ; Boutron-Ruault, M.-C.* ; Rohrmann, S.* ; Linseisen, J. ; Steffen, A.* ; Boeing, H.* ; May, A.M.* ; Peeters, P.H.* ; Bas Bueno-de-Mesquita, H.* ; van den Berg, S.W.* ; Dorronsoro, M.* ; Barricarte, A.* ; Rodriguez Suarez, L.* ; Navarro, C.* ; González, C.A.* ; Boffetta, P.* ; Pala, V.* ; Hallmans, G.* ; Trichopoulou, A.*

Weight change in later life and risk of death amongst the elderly: The European Prospective Investigation into Cancer and Nutrition-Elderly Network on Ageing and Health Study.

J. Intern. Med. 268, 133-144 (2010)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
OBJECTIVE: Later life weight change and mortality amongst elders. DESIGN: Nested case-control study. SETTING: Six countries from the European Investigation into Cancer and nutrition-Elderly, Network on Ageing and Health. SUBJECTS: A total of 1712 deceased (cases) and 4942 alive (controls) were selected from 34,239 participants, > or = 60 years at enrolment (1992-2000) who were followed-up until March 2007. Annual weight change was estimated as the weight difference from recruitment to the most distant from-date-of-death re-assessment, divided by the respective time. OUTCOME MEASURES: Mortality in relation to weight change was examined using conditional logistic regression. RESULTS: Weight loss > 1 kg year(-1) was associated with statistically significant increased death risk (OR = 1.65; 95% CI: 1.41-1.92) compared to minimal weight change (+/-1 kg year(-1)). Weight gain > 1 kg year(-1) was also associated with increased risk of death (OR = 1.15; 95% CI: 0.98-1.37), but this was evident and statistically significant only amongst overweight/obese (OR = 1.55; 95% CI: 1.17-2.05). In analyses by time interval since weight re-assessment, the association of mortality with weight loss was stronger for the interval proximal (< 1 year) to death (OR = 3.10; 95% CI: 2.03-4.72). The association of mortality with weight gain was stronger at the interval of more than 3 years and statistically significant only amongst overweight/obese (OR = 1.58; 95% CI: 1.07-2.33). Similar patterns were observed regarding death from circulatory diseases and cancer. CONCLUSIONS: In elderly, stable body weight is a predictor of lower subsequent mortality. Weight loss is associated with increased mortality, particularly short-term, probably reflecting underlying nosology. Weight gain, especially amongst overweight/obese elders, is also associated with increased mortality, particularly longer term.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Body mass index; Mortality; Obesity; Weight gain; Weight loss
ISSN (print) / ISBN 0954-6820
e-ISSN 1365-2796
Journal Journal of Internal Medicine
Quellenangaben Volume: 268, Issue: 2, Pages: 133-144 Article Number: , Supplement: ,
Publisher Wiley
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)