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Koch, M. ; Glatz, J. ; Ermolayev, V. ; de Vries, E.G.* ; van Dam, G.M.* ; Englmeier, K.-H. ; Ntziachristos, V.

Video-rate optical flow corrected intraoperative functional fluorescence imaging.

J. Biomed. Opt. 19:46012 (2014)
Publ. Version/Full Text DOI PMC
Open Access Gold
ABSTRACT. Intraoperative fluorescence molecular imaging based on targeted fluorescence agents is an emerging approach to improve surgical and endoscopic imaging and guidance. Short exposure times per frame and implementation at video rates are necessary to provide continuous feedback to the physician and avoid motion artifacts. However, fast imaging implementations also limit the sensitivity of fluorescence detection. To improve on detection sensitivity in video rate fluorescence imaging, we considered herein an optical flow technique applied to texture-rich color images. This allows the effective accumulation of fluorescence signals over longer, virtual exposure times. The proposed correction scheme is shown to improve signal-to-noise ratios both in phantom experiments and in vivo tissue imaging.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Fluorescence ; Infrared ; Motion ; Real-time Imaging; Indocyanine Green; Localization; Vision; Cancer; Era
Language english
Publication Year 2014
HGF-reported in Year 2014
ISSN (print) / ISBN 1083-3668
e-ISSN 1560-2281
Journal Journal of Biomedical Optics
Quellenangaben Volume: 19, Issue: 4, Pages: , Article Number: 46012 Supplement: ,
Publisher SPIE
Publishing Place Bellingham
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505500-001
G-505500-003
PubMed ID 24752380
DOI 10.1117/1.JBO.19.4.046012
WOS ID WOS:000338334300018
Scopus ID 84899580370
Erfassungsdatum 2014-04-24
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