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Open Access Green as soon as Postprint is submitted to ZB.
Canine embryonic stem cells: State of the art.
Theriogenology 74, 492-497 (2010)
Embryonic stem cells (ESCs) are permanent cell lines that can be maintained in a pluripotent, undifferentiated state. Appropriate environmental stimuli can cause them to differentiate into cell types of all three germ layers both in vitro and in vivo. Embryonic stem cells bear many opportunities for clinical applications in tissue engineering and regenerative medicine. Whereas most of our knowledge on the biology and technology of ESCs is derived from studies with mouse cells, large animal models mimicking important aspects of human anatomy, physiology, and pathology more closely than mouse models are urgently needed for studies evaluating the safety and efficacy of cell therapies. The dog is an excellent model for studying human diseases, and the availability of canine ESCs would open new possibilities for this model in biomedical research. In addition, canine ESCs could be useful for the development of cell-based approaches for the treatment of dogs. Here, we discuss the features of recently reported canine embryo-derived cells and their potential applications in basic and translational biomedical research.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Canine; Differentiation; Dog; Embryonic stem cells; Pluripotent stem cells
ISSN (print) / ISBN
0093-691X
e-ISSN
1879-3231
Journal
Theriogenology
Quellenangaben
Volume: 74,
Issue: 4,
Pages: 492-497
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
CCG Hematopoetic Cell Transplants (IMI-KHZ)