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Conrad, M. ; Friedmann Angeli, J.P.F.

Glutathione peroxidase 4 (Gpx4) and ferroptosis: What's so special about it?

Mol. Cell. Oncol. 2:e995047 (2015)
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The system XC−/glutathione/glutathione peroxidase 4 axis pivotally controls ferroptosis, a recently described form of regulated, non-apoptotic cell death. Compelling evidence established that this cell death route is of high relevance not only for triggering cancer cell death, but also proves to be amenable for therapeutic intervention to halt ischemia/reperfusion-related diseases.  
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Publication type Article: Journal article
Document type Scientific Article
Keywords Cell death; Lipid peroxidation; Non-apoptotic cell death; Regulated necrosis
Language english
Publication Year 2015
HGF-reported in Year 0
e-ISSN 2372-3556
Journal Molecular & Cellular Oncology
Quellenangaben Volume: 2, Issue: 3, Pages: , Article Number: e995047 Supplement: ,
Publisher Taylor & Francis
Reviewing status Peer reviewed
Institute(s) Institute of Developmental Genetics (IDG)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30204 - Cell Programming and Repair
Research field(s) Genetics and Epidemiology
PSP Element(s) G-500500-004
G-500500-001
PubMed ID 27308484
DOI 10.4161/23723556.2014.995047
Erfassungsdatum 2015-05-22
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