PuSH - Publication Server of Helmholtz Zentrum München: Uric acid levels are associated with all-cause and cardiovascular disease mortality independent of systemic inflammation in men from the general population: The MONICA/KORA cohort study.

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Meisinger, C. ; Koenig, W.* ; Baumert, J.J. ; Döring, A.

Uric acid levels are associated with all-cause and cardiovascular disease mortality independent of systemic inflammation in men from the general population: The MONICA/KORA cohort study.

Arterioscler. Thromb. Vasc. Biol. 28, 1186-1192 (2008)

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Open Access Green as soon as Postprint is submitted to ZB.

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The purpose of this study was to assess whether increasing serum uric acid (UA) levels are related to cardiovascular disease (CVD) mortality, all-cause mortality, and incident (fatal and nonfatal) myocardial infarction (MI) in men from the general population taking into account C-reactive protein (CRP), a sensitive marker of systemic inflammation. METHODS AND RESULTS: The study was based on 3604 men (45 to 74 years of age) who participated in 1 of the 3 MONICA Augsburg surveys between 1984 and 1995. All participants were prospectively followed within the framework of the Cooperative Health Research in the Region of Augsburg (KORA). Up to December 31, 2002, there occurred 809 total deaths, 359 CVD deaths, and 297 incident MIs. In a Cox model, comparing extreme quartiles of the UA distribution, the hazard ratio for CVD mortality was 1.44 (95% confidence interval [CI] 1.04 to 2.0), and for all-cause mortality it was 1.40 (95% CI 1.13 to 1.74) after adjustment for conventional cardiovascular risk factors, CRP, and diuretic intake. However, UA was not associated with incident MI after multivariable adjustment. CONCLUSIONS: High UA levels were independently associated with CVD mortality as well as all-cause mortality but not with incident MI in middle-aged men from the general population.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords men; mortality; risk factors; serum uric acid; C-reactive protein

ISSN (print) / ISBN 1079-5642

e-ISSN 1524-4636

Journal Arteriosclerosis, Thrombosis, and Vascular Biology

Quellenangaben Volume: 28, Issue: 6, Pages: 1186-1192

Publisher Lippincott Williams & Wilkins

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Epidemiology (EPI)