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Open Access Green as soon as Postprint is submitted to ZB.
Expression of raf kinase inhibitor protein is down regulated in response to newcastle disease virus infection to promote viral replication.
J. Gen. Virol. 96, 2579-2586 (2015)
Newcastle disease virus (NDV) causes a severe and economically significant disease affecting almost the entire poultry industry worldwide. However, factors that affect NDV replication in host cells are poorly understood. Raf kinase inhibitory protein (RKIP) is a physiological inhibitor of c-RAF kinase and NF-kB signalling, known for their functions in the control of immune response as well as tumour invasion and metastasis. In the present study, we investigated the consequences of overexpression of host RKIP during viral infection. We demonstrate that NDV infection represses RKIP expression thereby promoting virus replication. Experimental upregulation of RKIP in turn acts as a potential antiviral defence mechanism in host cells that restricts NDV replication by repressing the activation of Raf/MEK/ERK and IkBα/NF-kB signalling pathways. Our results not only extend the concept of linking NDV–host interactions, but also reveal RKIP as a new class of protein-kinase-inhibitor protein that affects NDV replication with therapeutic potential.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0022-1317
e-ISSN
1465-2099
Journal
Journal of General Virology
Quellenangaben
Volume: 96,
Issue: 9,
Pages: 2579-2586
Publisher
Society for General Microbiology
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Lung Health and Immunity (LHI)