PuSH - Publication Server of Helmholtz Zentrum München: Is there a march from early food sensitization to later childhood allergic airway disease? Results from two prospective birth cohort studies.

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

EVA: Electronic Publishing

New EVA Application

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Alduraywish, S.A.* ; Standl, M. ; Lodge, C.J.* ; Abramson, M.J.* ; Allen, K.J.* ; Erbas, B.* ; von Berg, A.* ; Heinrich, J. ; Lowe, A.J.* ; Dharmage, S.C.*

Is there a march from early food sensitization to later childhood allergic airway disease? Results from two prospective birth cohort studies.

Pediatr. Allergy Immunol. 28, 30-37 (2017)

Postprint

DOI

PMC

	Open Access Green

Abstract
Metrics
Extra information

BACKGROUND: The march from early aeroallergen sensitization to subsequent respiratory allergy is well established, but it is unclear if early life food sensitization precedes and further increases risk of allergic airway disease. OBJECTIVE: To assess the association between food sensitization in the first 2 years of life and subsequent asthma and allergic rhinitis by age 10-12 years. METHODS: We used data from two independent cohorts: the high-risk MACS (n=620) and the population-based LISAplus (n= 3094). Food sensitization was assessed at 6, 12 and 24 months in MACS and 24 months in LISAplus. Multiple logistic regressions were used to estimate associations between sensitization to food only, aeroallergen only or both and allergic airway disease. RESULTS: When compared to non-sensitized children, sensitization to food only at 12 months in MACS and 24 months in LISAplus was associated with increased risk of current asthma (aOR=2.2; 95%CI 1.1, 4.6 in MACS and aOR=4.9; 2.4,10.1 in LISAplus). Similar results were seen for allergic rhinitis. Additionally, co-sensitization to food and aeroallergen in both cohorts at any tested point was a stronger predictor of asthma (at 24 months, aOR=8.3; 3.7, 18.8 in MACS and aOR=14.4; 5.0, 41.6 in LISAplus) and allergic rhinitis (at 24 months, aOR=3.9;1.9,8.1 in MACS and aOR=7.6;3.0,19.6 in LISAplus). CONCLUSIONS: In both cohorts, food sensitization (with or without aeroallergen sensitization) in the first two years of life increased the risk of subsequent asthma and allergic rhinitis. These findings support the role of early life food sensitization in the atopic march and suggest trials to prevent early onset have the potential to reduce the development of allergic airways disease.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

3.775

0.932