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Kaloff, C. ; Anastassiadis, K.* ; Ayadi, A.* ; Baldock, R.* ; Beig, J. ; Birling, M.C.* ; Bradley, A.* ; Brown, S.D.M.* ; Bürger, A. ; Bushell, W.* ; Chiani, F.* ; Collins, F.S.* ; Doe, B.* ; Eppig, J.T.* ; Finnell, R.H.* ; Fletcher, C.* ; Flicek, P.* ; Fray, M.* ; Friedel, R.H.* ; Gambadoro, A.* ; Gates, H.* ; Hansen, J. ; Herault, Y.* ; Hicks, G.G.* ; Hörlein, A. ; Hrabě de Angelis, M. ; Iyer, V.* ; de Jong, P.J.* ; Koscielny, G.* ; Kühn, R. ; Liu, P.* ; Lloyd, K.C.K.* ; Lopez, R.G.* ; Marschall, S. ; Martínez, S.* ; McKerlie, C.* ; Meehan, T.F.* ; von Melchner, H.* ; Moore, M.* ; Murray, S.A.* ; Nagy, A.* ; Nutter, L.M.J.* ; Pavlovic, G.* ; Pombero, A.* ; Prosser, H.* ; Ramirez-Solis, R.* ; Ringwald, M.* ; Rosen, B.* ; Rosenthal, N.* ; Rossant, J.* ; Ruiz Noppinger, P.* ; Ryder, E.* ; Skarnes, W.C.* ; Schick, J. ; Schnütgen, F.* ; Schofield, P.* ; Seisenberger, C. ; Selloum, M.* ; Smedley, D.* ; Simpson, E.M.* ; Stewart, A.F.* ; Teboul, L.* ; Tocchini Valentini, G.P.* ; Valenzuela, D.* ; West, A.P.* ; Wurst, W.

Genome wide conditional mouse knockout resources.

Drug Discov. Today, DOI: 10.1016/j.ddmod.2017.08.002 (2017)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
© 2017 Elsevier Ltd. The International Knockout Mouse Consortium (IKMC) developed high throughput gene trapping and gene targeting pipelines that produced mostly conditional mutations of more than 18,500 genes in C57BL/6N mouse embryonic stem (ES) cells which have been archived and are freely available to the research community as a frozen resource. From this unprecedented resource more than 6000 mutant mouse strains have been generated by the IKMC in collaboration with the International Mouse Phenotyping Consortium (IMPC). In addition, a cre-driver resource was established including 250 C57BL/6 cre-inducible mouse strains. Complementing the cre-driver resource, a collection comprising 27 rAAVs expressing cre in a tissue-specific manner has also been produced. All resources are easily accessible from the IKMC/IMPC web portal (www.mousephenotype.org). The IKMC/IMPC resource is a standardized reference library of mouse models with defined genetic backgrounds enabling the analysis of gene-disease associations in mice of different genetic makeup and should therefore have a major impact on biomedical research.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 1359-6446
e-ISSN 1878-5832
Journal Drug discovery today
Publisher Elsevier
Publishing Place Cambridge
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Developmental Genetics (IDG)
Institute of Experimental Genetics (IEG)
Institute of Molecular Toxicology and Pharmacology (TOX)