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Tharmarajah, G.* ; Eckhard, U.* ; Jain, F.* ; Marino, G.* ; Prudova, A.* ; Urtatiz, O.* ; Fuchs, H. ; Hrabě de Angelis, M. ; Overall, C.M.* ; van Raamsdonk, C.D.*

Melanocyte development in the mouse tail epidermis requires the Adamts9 metalloproteinase.

Pigment Cell Melanoma Res. 31, 693-707 (2018)
Postprint DOI PMC
Open Access Green
The mouse tail has an important role in the study of melanogenesis, because mouse tail skin can be used to model human skin pigmentation. To better understand the development of melanocytes in the mouse tail, we cloned two dominant ENU-generated mutations of the Adamts9 gene, Und3 and Und4, which cause an unpigmented ring of epidermis in the middle of the tail, but do not alter pigmentation in the rest of the mouse. Adamts9 encodes a widely expressed zinc metalloprotease with thrombospondin type 1 repeats with few known substrates. Melanocytes are lost in the Adamts9 mutant tail epidermis at a relatively late stage of development, around E18.5. Studies of our Adamts9 conditional allele suggest that there is a melanocyte cell-autonomous requirement for Adamts9. In addition, we used a proteomics approach, TAILS N-terminomics, to identify new Adamts9 candidate substrates in the extracellular matrix of the skin. The tail phenotype of Adamts9 mutants is strikingly similar to the unpigmented trunk belt in Adamts20 mutants, which suggests a particular requirement for Adamts family activity at certain positions along the anteriorposterior axis.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Adamts ; Melanoblast Development ; Metalloproteinase ; Skin Pigmentation ; Tail; Uveal Melanoma; Mice; Mutations; Skin; Expression; Color; Gnaq
Language
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 1755-1471
e-ISSN 1755-148X
Journal Pigment Cell & Melanoma Research
Quellenangaben Volume: 31, Issue: 6, Pages: 693-707 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-500600-001
G-500600-003
DOI 10.1111/pcmr.12711
WOS ID WOS:000447306800006
Scopus ID 85054796832
PubMed ID 29781574
Erfassungsdatum 2018-05-22
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