PuSH - Publication Server of Helmholtz Zentrum München: Intraoperative multispectral fluorescence imaging for the detection of the sentinel lymph node in cervical cancer: A novel concept.

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Crane, L.M.A.* ; Themelis, G. ; Pleijhuis, R.G.* ; Harlaar, N.J. ; Sarantopoulos, A. ; Arts, H.J.* ; van der Zee, A.G.J.* ; Vasilis, N. ; van Dam, G.M.*

Intraoperative multispectral fluorescence imaging for the detection of the sentinel lymph node in cervical cancer: A novel concept.

Mol. Imaging Biol. 13, 1043-1049 (2011)

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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.

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PURPOSE: Real-time intraoperative near-infrared fluorescence (NIRF) imaging is a promising technique for lymphatic mapping and sentinel lymph node (SLN) detection. The purpose of this technical feasibility pilot study was to evaluate the applicability of NIRF imaging with indocyanin green (ICG) for the detection of the SLN in cervical cancer. PROCEDURES: In ten patients with early stage cervical cancer, a mixture of patent blue and ICG was injected into the cervix uteri during surgery. Real-time color and fluorescence videos and images were acquired using a custom-made multispectral fluorescence camera system. RESULTS: Real-time fluorescence lymphatic mapping was observed in vivo in six patients; a total of nine SLNs were detected, of which one (11%) contained metastases. Ex vivo fluorescence imaging revealed the remaining fluorescent signal in 11 of 197 non-sentinel LNs (5%), of which one contained metastatic tumor tissue. None of the non-fluorescent LNs contained metastases. CONCLUSIONS: We conclude that lymphatic mapping and detection of the SLN in cervical cancer using intraoperative NIRF imaging is technically feasible. However, the technique needs to be refined for full applicability in cervical cancer in terms of sensitivity and specificity.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Cervical cancer; Near-infrared fluorescence; Sentinel lymph node; Multispectral intraoperative imaging

ISSN (print) / ISBN 1536-1632

e-ISSN 1860-2002

Journal Molecular Imaging and Biology

Quellenangaben Volume: 13, Pages: 1043-1049

Publisher Elsevier

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Biological and Medical Imaging (IBMI)