PuSH - Publication Server of Helmholtz Zentrum München: Lipid droplets accumulate in the hypothalamus of mice and humans with and without metabolic diseases.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Maya-Monteiro, C.M.* ; Corrêa-da-Silva, F.* ; Hofmann, S.M. ; Hesselink, M.K.C.* ; la Fleur, S.E.* ; Yi, C.X.*

Lipid droplets accumulate in the hypothalamus of mice and humans with and without metabolic diseases.

Neuroendocrinology 111, 263-272 (2021)

Publ. Version/Full Text

Research data

DOI

PMC

	Open Access Gold (Paid Option)

Abstract
Metrics
Extra information

Background: In peripheral tissues, the lipid droplet (LD) organelle links lipid metabolism, inflammation, and insulin resistance. Little is known about the brain LDs. Objectives: We hypothesized that hypothalamic LDs would be altered in metabolic diseases. Methods: We used immunofluorescence labeling of the specific LD protein, PLIN2, as the approach to visualize and quantify LDs. Results: LDs were abundant in the hypothalamic third ventricle wall layer with similar heterogeneous distributions between control mice and humans. The LD content was enhanced by high-fat diet (HFD) in both wild-type and in low-density lipoprotein receptor deficient (Ldlr-/-HFD) mice. Strikingly, we observed a lower LD amount in type 2 diabetes mellitus (T2DM) patients when compared with non-T2DM patients. Conclusions: LDs accumulate in the normal hypothalamus, with similar distributions in human and mouse. Moreover, metabolic diseases differently modify LD content in mouse and human. Our results suggest that hypothalamic LD accumulation is an important target to the study of metabolism.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Hypothalamus ; Insulin Resistance ; Lipid Droplet ; Plin2 ; Type 2 Diabetes Mellitus

ISSN (print) / ISBN 0028-3835

e-ISSN 1423-0194

Journal Neuroendocrinology

Quellenangaben Volume: 111, Issue: 3, Pages: 263-272

Publisher Karger

Publishing Place Allschwilerstrasse 10, Ch-4009 Basel, Switzerland

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Diabetes and Regeneration Research (IDR)

Grants Deutsche Forschungsgemeinschaft (German Research Foundation)
Netherlands Organization of Scientific Research (NWO-VICI)
Dutch Diabetes Research Foundation
AMC fellowship
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
Instituto Oswaldo Cruz (IOC)
Fundacao Oswaldo Cruz (FIOCRUZ)