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Hyytiäinen, H.* ; Kirjavainen, P.V.* ; Täubel, M.* ; Tuoresmäki, P.* ; Casas, L.* ; Heinrich, J. ; Herberth, G.* ; Standl, M. ; Renz, H.* ; Piippo-Savolainen, E.* ; Hyvärinen, A.* ; Pekkanen, J.* ; Karvonen, A.M.*

Microbial diversity in homes and the risk of allergic rhinitis and inhalant atopy in two European birth cohorts.

Environ. Res. 196:110835 (2021)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
BACKGROUND: Microbial exposures in early childhood direct the development of the immune system and their diversity may influence the risk of allergy development. We aimed to determine whether the indoor microbial diversity at early-life is associated with the development of allergic rhinitis and inhalant atopy. METHODS: The study population included children within two birth cohorts: Finnish rural-suburban LUKAS (N=312), and German urban LISA from Munich and Leipzig study centers (N=248). The indoor microbiota diversity (Chao1 richness and Shannon entropy) was characterized from floor dust samples collected at the child age of 2-3 months by Illumina MiSeq sequencing of bacterial and fungal DNA amplicons. Allergic rhinitis and inhalant atopy were determined at the age of 10 years and analyzed using logistic regression models. RESULTS: High bacterial richness (aOR 0.19, 95%CI 0.09-0.42 for middle and aOR 0.12, 95%CI 0.05-0.29 for highest vs. lowest tertile) and Shannon entropy were associated with lower risk of allergic rhinitis in LISA, and similar trend was seen in LUKAS. We observed some significant associations between bacterial and fungal diversity measured and the risk of inhalant atopy, but the associations were inconsistent between the two cohorts. High bacterial diversity tended to be associated with increased risk of inhalant atopy in rural areas, but lower risk in more urban areas. Fungal diversity tended to be associated with increased risk of inhalant atopy only in LISA. CONCLUSIONS: Our study suggests that a higher bacterial diversity may reduce the risk of allergic rhinitis later in childhood. The environment-dependent heterogeneity in the associations with inhalant atopy - visible here as inconsistent results between two differing cohorts - suggests that specific constituents of the diversity may be relevant.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Allergic Rhinitis ; Indoor Microbiota ; Inhalant Atopy ; Microbial Diversity; House-dust Endotoxin; Respiratory Symptoms; Childhood Asthma; Early-life; Exposure; Children; Dna; Rhinoconjunctivitis; Sensitization
ISSN (print) / ISBN 0013-9351
e-ISSN 1096-0953
Zeitschrift Environmental Research
Quellenangaben Band: 196, Heft: , Seiten: , Artikelnummer: 110835 Supplement: ,
Verlag Elsevier
Verlagsort San Diego, Calif.
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
Förderungen Kerttu and Kalle Viik Foundation
Competitive State Research Funding for the Kuopio University Hospital Catchment Area
Foundation for Pediatric Research
Yrjo Jahnsson Foundation
Juho Vainio Foundation
Paivikki and Sakari Sohlberg Foundation
Finnish Cultural Foundation
Finnish Institute for Health and Welfare, Finland
Kuopio Area Respiratory Foundation
Research Foundation Flanders (FWO)
Commission of the European Communities
Federal Ministry for Environment
IUF - Leibniz-Research Institute for Environmental Medicine at the University of Dusseldorf
Research Institute at Marien-Hospital Wesel, Pediatric Practice, Bad Honnef
Helmholtz Centre for Environmental Research - UFZ, Leipzig
Helmholtz Zentrum Munich
Federal Ministry for Education, Science, Research and Technology
Academy of Finland