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The role of virome in the gastrointestinal tract and beyond.
FEMS Microbiol. Rev. 46:fuac027 (2022)
Publ. Version/Full Text
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DOI
PMC
The human gut virome is comprised of diverse commensal and pathogenic viruses. The colonization by these viruses begins right after birth through vaginal delivery, then continues through breastfeeding, and broader environmental exposure. Their constant interaction with their bacterial hosts in the body shapes not only our microbiomes but us. In addition, these viruses interact with the immune cells, trigger a broad range of immune responses, and influence different metabolic pathways. Besides its key role in regulating the human gut homeostasis, the intestinal virome contributes to disease development in distant organs, both directly and indirectly. In this review, we will describe the changes in the gut virome through life, health, and disease, followed by discussing the interactions between the virome, the microbiome, and the human host as well as providing an overview of their contribution to gut disease and disease of distant organs.
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Publication type
Article: Journal article
Document type
Review
Keywords
Virome ; Microbiome ; Gastrointestinal Tract ; Phageome ; Immune Response ; Auxiliary Metabolic Genes
ISSN (print) / ISBN
0168-6445
Quellenangaben
Volume: 46,
Issue: 6,
Article Number: fuac027
Publisher
Wiley
Publishing Place
Malden, Mass.
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Virology (VIRO)