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Ying, S.* ; Pettengill, M.* ; Latham, E.R.* ; Walch, A.K. ; Ojcius, D.M.* ; Häcker, G.*

Premature apoptosis of Chlamydia-infected cells disrupts chlamydial development.

J. Infect. Dis. 198, 1536-1544 (2008)
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The obligate intracellular development of Chlamydia suggests that the bacteria should be vulnerable to premature host cell apoptosis, but because Chlamydia-infected cells are apoptosis resistant, this has never been able to be tested. We have devised a system to circumvent the apoptotic block imposed by chlamydial infection. When the proapoptotic protein BimS was experimentally induced, epithelial cells underwent apoptosis that was not blocked by chlamydial infection. Apoptosis during the developmental cycle prevented the generation of infectious bacteria and caused transcriptional changes of bacterial genes and loss of intracellular ATP. Intriguingly, although apoptosis resulted in destruction of host cell structures and of the Chlamydia inclusion, and prevented generation of elementary bodies, BimS induction in the presence of a caspase inhibitor allowed differentiation into morphologically normal but noninfectious elementary bodies. These data show that chlamydial infection renders host cells apoptosis resistant at a premitochondrial step and demonstrate the consequences of premature apoptosis for development of the bacteria.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2008
HGF-reported in Year 2008
ISSN (print) / ISBN 0022-1899
e-ISSN 1537-6613
Journal Journal of Infectious Diseases, The
Quellenangaben Volume: 198, Issue: 10, Pages: 1536-1544 Article Number: , Supplement: ,
Publisher Oxford University Press
Reviewing status Peer reviewed
Institute(s) Institute of Pathology (PATH)
Research Unit Analytical Pathology (AAP)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-500300-001
G-500390-001
DOI 10.1086/592755
Scopus ID 54949114751
Erfassungsdatum 2008-12-09
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