PuSH - Publication Server of Helmholtz Zentrum München: Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Kamiza, A.B.* ; Touré, S.M.* ; Zhou, F.* ; Soremekun, O.* ; Cissé, C.* ; Wélé, M.* ; Touré, A.M.* ; Nashiru, O.* ; Corpas, M.* ; Nyirenda, M.* ; Crampin, A.* ; Shaffer, J.* ; Doumbia, S.* ; Zeggini, E. ; Morris, A.P.* ; Asimit, J.L.* ; Chikowore, T.* ; Fatumo, S.

Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry.

Nat. Commun. 14:5403 (2023)

Publ. Version/Full Text

DOI

PMC

	Open Access Gold

Abstract
Metrics
Extra information

Most genome-wide association studies (GWAS) for lipid traits focus on the separate analysis of lipid traits. Moreover, there are limited GWASs evaluating the genetic variants associated with multiple lipid traits in African ancestry. To further identify and localize loci with pleiotropic effects on lipid traits, we conducted a genome-wide meta-analysis, multi-trait analysis of GWAS (MTAG), and multi-trait fine-mapping (flashfm) in 125,000 individuals of African ancestry. Our meta-analysis and MTAG identified four and 14 novel loci associated with lipid traits, respectively. flashfm yielded an 18% mean reduction in the 99% credible set size compared to single-trait fine-mapping with JAM. Moreover, we identified more genetic variants with a posterior probability of causality >0.9 with flashfm than with JAM. In conclusion, we identified additional novel loci associated with lipid traits, and flashfm reduced the 99% credible set size to identify causal genetic variants associated with multiple lipid traits in African ancestry.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Genome; Resource; Risk

ISSN (print) / ISBN 2041-1723

e-ISSN 2041-1723

Journal Nature Communications

Quellenangaben Volume: 14, Issue: 1, Article Number: 5403

Publisher Nature Publishing Group

Publishing Place London

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Translational Genomics (ITG)

Grants FIC NIH HHS
Medical Research Council