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Hagemann, T. ; Czechowski, P. ; Ghosh, A.* ; Sun, W.* ; Dong, H.* ; Noé, F.* ; Wolfrum, C.* ; Blüher, M. ; Hoffmann, A.

Laminin α4 expression in human adipose tissue depots and its association with obesity and obesity related traits.

Biomedicines 11:11 (2023)

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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.

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Laminin α4 (LAMA4) is one of the main structural adipocyte basement membrane (BM) components that is upregulated during adipogenesis and related to obesity in mice and humans. We conducted RNA-seq-based gene expression analysis of LAMA4 in abdominal subcutaneous (SC) and visceral (VIS) adipose tissue (AT) depots across three human sub-cohorts of the Leipzig Obesity BioBank (LOBB) to explore the relationship between LAMA4 expression and obesity (N = 1479) in the context of weight loss (N = 65) and metabolic health (N = 42). We found significant associations of LAMA4 with body fat mass (p < 0.001) in VIS AT; higher expression in VIS AT compared to SC AT; and significant relation to metabolic health parameters e.g., body fat in VIS AT, waist (p = 0.009) and interleukin 6 (p = 0.002) in male VIS AT, and hemoglobin A1c (p = 0.008) in male SC AT. AT LAMA4 expression was not significantly different between subjects with or without obesity, metabolically healthy versus unhealthy, and obesity before versus after short-term weight loss. Our results support significant associations between obesity related clinical parameters and elevated LAMA4 expression in humans. Our work offers one of the first references for understanding the meaning of LAMA4 expression specifically in relation to obesity based on large-scale RNA-seq data.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Lama4 ; Rna-seq ; Adipose Tissue ; Laminin α4 ; Metabolic Health ; Obesity ; Type 2 Diabetes; Cardiovascular-disease; Risk; Cells

ISSN (print) / ISBN 2227-9059

e-ISSN 2227-9059

Journal Biomedicines

Quellenangaben Volume: 11 Issue: 10, Article Number: 11

Publisher MDPI

Publishing Place Basel, Switzerland

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)

Grants We thank all patients and their families for participating in this study.