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de Sá E Silva, D.M.* ; Thaitumu, M.* ; Theodoridis, G.* ; Witting, M. ; Gika, H.*

Volumetric absorptive microsampling in the analysis of endogenous metabolites.

Metabolites 13:24 (2023)
DOI PMC
Creative Commons Lizenzvertrag
Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Volumetric absorptive microsampling (VAMS) has arisen as a relevant tool in biological analysis, offering simplified sampling procedures and enhanced stability. Most of the attention VAMS has received in the past decade has been from pharmaceutical research, with most of the published work employing VAMS targeting drugs or other exogenous compounds, such as toxins and pollutants. However, biomarker analysis by employing blood microsampling has high promise. Herein, a comprehensive review on the applicability of VAMS devices for the analysis of endogenous metabolites/biomarkers was performed. The study presents a full overview of the analysis process, incorporating all the steps in sample treatment and validation parameters. Overall, VAMS devices have proven to be reliable tools for the analysis of endogenous analytes with biological importance, often offering improved analyte stability in comparison with blood under ambient conditions as well as a convenient and straightforward sample acquisition model.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Analytical Validation ; Biomarkers ; Blood Microsampling ; Clinical Application ; Endogenous Metabolites ; Volumetric Absorptive Microsampling (vams); Whole-blood; Quantitative Bioanalysis; Lc-ms/ms; Thiamine Status; Hematocrit; Devices; Plasma; Vams; Quantification; Validation
ISSN (print) / ISBN 2218-1989
e-ISSN 2218-1989
Journal Metabolites
Quellenangaben Volume: 13, Issue: 10, Pages: , Article Number: 24 Supplement: ,
Publisher MDPI
Publishing Place St Alban-anlage 66, Ch-4052 Basel, Switzerland
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) CF Metabolomics & Proteomics (CF-MPC)
Grants Marie Curie Actions (MSCA)
European Union Horizon 2020, Marie Curie Actions