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Stein, R. ; Koutny, F.* ; Riedel, J.* ; Doerr, N.* ; Meyer, K. ; Colombo, M.* ; Vogel, M.* ; Anderwald, C.H.* ; Blüher, M. ; Kiess, W.* ; Körner, A. ; Weghuber, D.*

Single point insulin sensitivity estimator (SPISE) as a prognostic marker for emerging dysglycemia in children with overweight or obesity.

Metabolites 13:12 (2023)

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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.

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The single point insulin sensitivity estimator (SPISE) is a recently developed fasting index for insulin sensitivity based on triglycerides, high density lipoprotein cholesterol, and body mass index. SPISE has been validated in juveniles and adults; still, its role during childhood remains unclear. To evaluate the age- and sex-specific distribution of SPISE, its correlation with established fasting indexes and its application as a prognostic marker for future dysglycemia during childhood and adolescence were assessed. We performed linear modeling and correlation analyses on a cross-sectional cohort of 2107 children and adolescents (age 5 to 18.4 years) with overweight or obesity. Furthermore, survival analyses were conducted upon a longitudinal cohort of 591 children with overweight/obesity (1712 observations) with a maximum follow-up time of nearly 20 years, targeting prediabetes/dysglycemia as the end point. The SPISE index decreased significantly with age (-0.34 units per year, p < 0.001) among children and adolescents with overweight and obesity. Sex did not have an influence on SPISE. There was a modest correlation between SPISE and established fasting markers of insulin resistance (R = -0.49 for HOMA-IR, R = -0.55 for QUICKI-IR). SPISE is a better prognostic marker for future dysglycemia (hazard ratio (HR) 3.47, 95% confidence interval (CI) 1.60-7.51, p < 0.01) than HOMA-IR and QUICKI-IR (HR 2.44, 95% CI 1.24-4.81, p < 0.05). The SPISE index is a surrogate marker for insulin resistance predicting emerging dysglycemia in children with overweight or obesity, and could, therefore, be applied to pediatric cohorts that lack direct insulin assessment.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords SPISE; childhood obesity; dysglycemia; early-onset diabetes; prediabetes; type 2 diabetes; insulin resistance; Hdl Cholesterol Ratio; Resistance; Glucose; Triglyceride; Adolescents; Index

ISSN (print) / ISBN 2218-1989

e-ISSN 2218-1989

Journal Metabolites

Quellenangaben Volume: 13, Issue: 1, Article Number: 12

Publisher MDPI

Publishing Place St Alban-anlage 66, Ch-4052 Basel, Switzerland

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)

Grants Helmholtz Institute for Metabolic, Obesity and Vascular Research of the Helmholtz Zentrum Muenchen at the University of Leipzig
joint Clinician Scientist Programme of the Medical Faculty
German Diabetes Association (DDG)
Free State of Saxony
European Regional Development Fund
Leipzig Research Center for Civilization Diseases (LIFE Child), University of Leipzig - European Union