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Varkevisser, R.D.M.* ; Cecil, A. ; Prehn, C. ; Mul, D.* ; Aanstoot, H.J.* ; Paterson, A.D.* ; Wolffenbuttel, B.H.R.* ; van der Klauw, M.M.*

Metabolomic associations of impaired awareness of hypoglycaemia in type 1 diabetes.

Sci. Rep. 14:4485 (2024)
DOI PMC
Creative Commons Lizenzvertrag
This study investigates impaired awareness of hypoglycaemia (IAH), a complication of insulin therapy affecting 20-40% of individuals with type 1 diabetes. The exact pathophysiology is unclear, therefore we sought to identify metabolic signatures in IAH to elucidate potential pathophysiological pathways. Plasma samples from 578 individuals of the Dutch type 1 diabetes biomarker cohort, 67 with IAH and 108 without IAH (NAH) were analysed using the targeted metabolomics Biocrates AbsoluteIDQ p180 assay. Eleven metabolites were significantly associated with IAH. Genome-wide association studies of these 11 metabolites identified significant single nucleotide polymorphisms (SNPs) in C22:1-OH and phosphatidylcholine diacyl C36:6. After adjusting for the SNPs, 11 sphingomyelins and phosphatidylcholines were significantly higher in the IAH group in comparison to NAH. These metabolites are important components of the cell membrane and have been implicated to play a role in cell signalling in diabetes. These findings demonstrate the potential role of phosphatidylcholine and sphingomyelins in IAH.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Lessons; Pathway
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Quellenangaben Volume: 14, Issue: 1, Pages: , Article Number: 4485 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Grants Dutch Diabetes Research Foundation
Juvenile Diabetes Research Foundation (JDRF)