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Pudelko, L ; Cabianca, D.S.

The influencers' era: How the environment shapes chromatin in 3D.

Curr. Opin. Genet. Dev. 85:102173 (2024)
DOI PMC
Creative Commons Lizenzvertrag
Environment-epigenome interactions are emerging as contributors to disease risk and health outcomes. In fact, organisms outside of the laboratory are constantly exposed to environmental changes that can influence chromatin regulation at multiple levels, potentially impacting on genome function. In this review, we will summarize recent findings on how major external cues impact on 3D chromatin organization in different experimental systems. We will describe environment-induced 3D genome alterations ranging from chromatin accessibility to the spatial distribution of the genome and discuss their role in regulating gene expression.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Long-range Interactions; Life-span Extension; Nuclear Architecture; Stress; Genome; Orchestrate; Principles; Elegans; Calcium; Mg2+
ISSN (print) / ISBN 0959-437X
e-ISSN 1879-0380
Journal Current Opinion in Genetics & Development
Quellenangaben Volume: 85, Issue: , Pages: , Article Number: 102173 Supplement: ,
Publisher Elsevier
Publishing Place 84 Theobalds Rd, London Wc1x 8rr, England
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Functional Epigenetics (IFE)
Grants
Helmholtz Munich
German Research Foundation (Deutsche Forschungsgemeinschaft DFG)