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Gruber, T.* ; Lechner, F. ; Krieger, J.P.* ; García-Cáceres, C.

Neuroendocrine gut-brain signaling in obesity.

Trends Endocrinol. Metab. 36, 42-54 (2024)
Publ. Version/Full Text DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
The past decades have witnessed the rise and fall of several, largely unsuccessful, therapeutic attempts to bring the escalating obesity pandemic to a halt. Looking back to look ahead, the field has now put its highest hopes in translating insights from how the gastrointestinal (GI) tract communicates with the brain to calibrate behavior, physiology, and metabolism. A major focus of this review is to summarize the latest advances in comprehending the neuroendocrine aspects of this so-called 'gut-brain axis' and to explore novel concepts, cutting-edge technologies, and recent paradigm-shifting experiments. These exciting insights continue to refine our understanding of gut-brain crosstalk and are poised to promote the development of additional therapeutic avenues at the dawn of a new era of antiobesity therapeutics.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Glp1 ; Brainstem ; Gut–brain Axis ; Obesity ; Oxytocin ; Vagus Nerve; Glucagon-like Peptide-1; Nucleus-tractus-solitarius; Food-intake; Paraventricular Nucleus; Sensory Neurons; Vagal Afferent; Stem-cells; Oxytocin; Cholecystokinin; Secretion
ISSN (print) / ISBN 1043-2760
e-ISSN 1879-3061
Journal Trends in Endocrinology and Metabolism
Quellenangaben Volume: 36, Issue: 1, Pages: 42-54 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
Grants Alexander von Humboldt foundation via the Feodor Lynen Post-doctoral fellowship
German Research Foundation DFG under Germany's Excellence Strategy within the framework of the Munich Cluster for Systems Neurology
Helmholtz Excelence Network
Swedish Research Council
Boehringer Ingelheim via an OpnMe project