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Woeckel, M. ; Rospleszcz, S. ; Wolf, K. ; Breitner-Busch, S. ; Ingrisch, M.* ; Bamberg, F.* ; Ricke, J.* ; Schlett, C.L.* ; Storz, C.* ; Schneider, A.E. ; Stoecklein, S.* ; Peters, A.

Association between long-term exposure to traffic-related air pollution and cardio-metabolic phenotypes: An MRI data-based analysis.

Environ. Sci. Technol. 58, 18064-18075 (2024)

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Long-term exposure to traffic-related air pollution (TRAP) is associated with cardiometabolic disease; however, its role in subclinical stages of disease development is unclear. Thus, we aimed to explore this association in a cross-sectional analysis, with cardiometabolic phenotypes derived from magnetic resonance imaging (MRI). Phenotypes of the left (LV) and right cardiac ventricle, whole-body adipose tissue (AT), and organ-specific AT were obtained by MRI in 400 participants of the KORA cohort. Land-use regression models were used to estimate residential long-term exposures to TRAP, e.g., nitrogen dioxides (NO₂) or particle number concentration (PNC). Associations between TRAP and MRI phenotypes were modeled using linear regression. Participants' mean age was 56 ± 9 years, and 42% were female. Long-term exposure to TRAP was associated with decreased LV wall thickness; a 6.0 μg/m³ increase in NO₂ was associated with a -1.9% [95% confidence interval: -3.7%; -0.1%] decrease in mean global LV wall thickness. Furthermore, we found associations between TRAP and increased cardiac AT. A 2,242 n/cm³ increase in PNC was associated with a 4.3% [-1.7%; 10.4%] increase in mean total cardiac AT. Associations were more pronounced in women and in participants with diabetes. Our exploratory study indicates that long-term exposure to TRAP is associated with subclinical cardiometabolic disease states, particularly in metabolically vulnerable subgroups.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Cardiometabolic Disease ; Cross-sectional Study ; Magnetic Resonance Imaging ; Traffic-related Air Pollution ; Ultrafine Particles; Particulate Matter Exposure; Residential Proximity; Major Roadways; Heart; Population; Pm2.5; Particles; Disease; Models; Kora

ISSN (print) / ISBN 0013-936X

e-ISSN 1520-5851

Journal Environmental Science & Technology

Quellenangaben Volume: 58, Issue: 41, Pages: 18064-18075

Publisher ACS

Publishing Place Washington, DC

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Epidemiology (EPI)

Grants Siemens Healthcare
German Centre for Cardiovascular Disease Research (Berlin, Germany)
Centre for Diabetes Research (DZD e.V., Neuherberg, Germany)
German Research Foundation (DFG, Deutsche Forschungsgemeinschaft)
State of Bavaria
Helmholtz Zentrum Munchen-German Research Center for Environmental Health - German Federal Ministry of Education and Research (BMBF)