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Jost, G.* ; Golfier, S.* ; Pietsch, H.* ; Lengsfeld, P.* ; Voth, M.* ; Schmid, T.E.* ; Eckardt-Schupp, F. ; Schmid, E.*

The influence of x-ray contrast agents in computed tomography on the induction of dicentrics and γ-H2AX foci in lymphocytes of human blood samples.

Phys. Med. Biol. 54, 6029-6039 (2009)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The aim of this study was to investigate and quantify two biomarkers for radiation exposure (dicentrics and gamma-H2AX foci) in human lymphocytes after CT scans in the presence of an iodinated contrast agent. Blood samples from a healthy donor were exposed to CT scans in the absence or presence of iotrolan 300 at iodine concentrations of 5 or 50 mg ml(-1) blood. The samples were exposed to 0.025, 0.05, 0.1 and 1 Gy in a tissue equivalent body phantom. Chromosome aberration scoring and automated microscopic analysis of gamma-H2AX foci were performed in parts of the same samples. The theoretical physical dose enhancement factor (DEF) was calculated on the basis of the mass energy-absorption coefficients of iodine and blood and the photon energy spectrum of the CT tube. No significant differences in the yields of dicentrics and gamma-H2AX foci were observed in the absence or presence of 5 mg iodine ml(-1) blood up to 0.1 Gy, whereas at 1 Gy the yields were elevated for both biomarkers. At an iodine concentration of 50 mg ml(-1) serving as a positive control, a biological DEF of 9.5 +/- 1.4 and 2.3 +/- 0.5 was determined for dicentrics and gamma-H2AX foci, respectively. A physical DEF of 1.56 and 6.30 was calculated for 5 and 50 mg iodine ml(-1), respectively. Thus, it can be concluded that in the diagnostic dose range (radiation and contrast dose), no relevant biological dose-enhancing effect could be detected, whereas a clear biological dose-enhancing effect could be found for a contrast dose well outside the diagnostic CT range for the complete radiation dose range with both methods.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Human peripheral lymphocytes; Biological effectiveness; Synchrotron-radiation; Enhanced radiotherapy; Secondary electrons; Excretory urography; Chromosomes; Media; Exposure; Aberrations
Sprache
Veröffentlichungsjahr 2009
HGF-Berichtsjahr 2010
ISSN (print) / ISBN 0031-9155
e-ISSN 1361-6560
Zeitschrift Physics in Medicine and Biology
Quellenangaben Band: 54, Heft: 20, Seiten: 6029-6039 Artikelnummer: , Supplement: ,
Verlag Institute of Physics Publishing (IOP)
Verlagsort Bristol
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Biology (ISB)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
PSP-Element(e) G-500200-002
DOI 10.1088/0031-9155/54/20/001
Scopus ID 70449086291
PubMed ID 19779223
Erfassungsdatum 2009-12-31
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