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Butterfield, L.H.* ; Disis, M.L.* ; Fox, BA.* ; Lee, PP.* ; Khleif, SN.* ; Thurin, M.* ; Trinchieri, G.* ; Wang, E.* ; Wigginton, J.* ; Chaussabel, D.* ; Coukos, G.* ; Dhodapkar, M.* ; Håkansson, L.* ; Janetzki, S.* ; Kleen, T.O.* ; Kirkwood, J.M.* ; Maccalli, C.* ; Maecker, H.* ; Maio, M.* ; Malyguine, A.* ; Masucci, G.* ; Palucka, A.K.* ; Potter, D.M.* ; Ribas, A.* ; Rivoltini, L.* ; Schendel, D.J.* ; Seliger, B.* ; Selvan, S.* ; Slingluff Jr., C.L.* ; Stroncek, D.F.* ; Streicher, H.* ; Wu, X.* ; Zeskind, B.* ; Zhao, Y.* ; Zocca, M.B.* ; Zwierzina, H.* ; Marincola, F.M.*

A systematic approach to biomarker discovery; Preamble to "the iSBTc-FDA taskforce on immunotherapy biomarkers".

J. Transl. Med. 6:81 (2008)
Verlagsversion Volltext DOI PMC
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The International Society for the Biological Therapy of Cancer (iSBTc) has initiated in collaboration with the United States Food and Drug Administration (FDA) a programmatic look at innovative avenues for the identification of relevant parameters to assist clinical and basic scientists who study the natural course of host/tumor interactions or their response to immune manipulation. The task force has two primary goals: 1) identify best practices of standardized and validated immune monitoring procedures and assays to promote inter-trial comparisons and 2) develop strategies for the identification of novel biomarkers that may enhance our understating of principles governing human cancer immune biology and, consequently, implement their clinical application. Two working groups were created that will report the developed best practices at an NCI/FDA/iSBTc sponsored workshop tied to the annual meeting of the iSBTc to be held in Washington DC in the Fall of 2009. This foreword provides an overview of the task force and invites feedback from readers that might be incorporated in the discussions and in the final document.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Editorial
Schlagwörter CYTOKINE FLOW-CYTOMETRY; EXPRESSION ANALYSIS; CANCER; CELLS; INTERLEUKIN-2; TETRAMER; ELISPOT; CRYOPRESERVATION; MELANOMA; THERAPY
Sprache englisch
Veröffentlichungsjahr 2008
HGF-Berichtsjahr 0
ISSN (print) / ISBN 1479-5876
e-ISSN 1479-5876
Quellenangaben Band: 6, Heft: , Seiten: , Artikelnummer: 81 Supplement: ,
Verlag BioMed Central
Begutachtungsstatus Peer reviewed
POF Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er)
Immune Response and Infection
PSP-Element(e) G-501700-005
G-501700-001
G-501700-002
G-520400-001
PubMed ID 19105846
Erfassungsdatum 2008-12-31