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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Use of the individual data of the a-bomb survivors for biologically based cancer models.
Radiat. Environ. Biophys. 49, 39-46 (2010)
All recent analyses of the data on solid cancer incidence of the atomic bomb survivors are corrected for migration and random dose errors. In the usual treatment with grouped data and regression calibration, the calibration of doses depends on the used dose response. For solid cancers, it usually is linear. Here, an individual likelihood is presented which works without further adjustment for all dose responses. When the same assumptions are made as in the usual Poisson regression, equivalent results are obtained. But, the individual likelihood has the potential to use more detailed models for dose errors and to estimate non-linear dose responses without recalibration. As an example for the potential of the individual data set for the analysis of risk at low doses, signals for a saturating bystander effect are investigated.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
1.787
0.720
3
4
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
atomic bomb survivers; individual likelihood; dose uncertainties; low dose; bystander effect
Sprache
englisch
Veröffentlichungsjahr
2010
Prepublished im Jahr
2009
HGF-Berichtsjahr
2010
ISSN (print) / ISBN
0301-634X
e-ISSN
1432-2099
Zeitschrift
Radiation and Environmental Biophysics
Quellenangaben
Band: 49,
Heft: 1,
Seiten: 39-46
Verlag
Springer
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Radiation Protection (ISS)
POF Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er)
Radiation Sciences
PSP-Element(e)
G-501100-006
PubMed ID
19908056
Scopus ID
77049127994
Erfassungsdatum
2009-12-31